Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review

Melville, James C.; Menegotto, Kelsey D.; Woernley, Timothy C.; Maida, Blake; Alava, Ibrahim

doi:10.1016/j.joms.2017.06.033

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…The most widely practiced reductive procedures for true macroglossia are keyhole techniques described by Morgan et al 16 and resection and approximation of the tongue by Köle [17][18][19][20][21] . The keyhole technique is preferred to reduce the central bulk of the tongue.…”

Section: Discussionmentioning

confidence: 99%

“…As most residual lesions are asymptomatic, it is worthwhile to compromise the completeness of resection to leave adequate tongue tissue for a better functional outcome. Residual lymphatic malformations, which are exacerbated with upper respiratory tract infections, can be managed with antibiotics 19 . Larger lesions on the tongue and neck can be addressed with sclerotherapy with or without re-excision or debulking.…”

Section: Discussionmentioning

confidence: 99%

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Functional outcomes in children with reduction glossectomy for vascular malformations - "less is more!"

Thomas

Gaikwad

Telugu

et al. 2021

JKAOMS

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Objectives: Vascular malformation (VM) of the tongue can cause true macroglossia in children. Reduction glossectomy provides primary relief when sclerotherapy has failed or is not possible. In this study, we evaluated the surgical role in functional outcome of reduction glossectomy performed for VM of the tongue. Patients and Methods: We evaluated the functional and surgical outcomes of seven children who were treated at a tertiary care centre in Southern India between 2013 and 2018. Results: Six children underwent median glossectomy, while one child underwent lateral glossectomy. Functional assessment was performed at least 2 years after the date of surgery. At the time of assessment, speech was comprehensible for three children and was occasionally unintelligible in four children. Taste and swallowing were normal in all seven children. Six children exhibited a minimal residual lesion after surgery, of which only one was symptomatic. Residual lesions were managed with sclerotherapy (n=3), observation (n=2), or repeat surgery (n=1). Conclusion: Reduction glossectomy in children with macroglossia secondary to VMs has acceptable outcomes in terms of cosmesis and speech, with no gastronomic restriction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Functional outcomes in children with reduction glossectomy for vascular malformations - "less is more!"

Thomas

Gaikwad

Telugu

et al. 2021

JKAOMS

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“…The outlook for recovery and eventual shrinkage of tongue size is excellent once thyroid replacement is stabilized. In rare cases and especially if severe obstruction to airways and food swallowing, surgical reduction in the tongue may be required ( 340 ).…”

Section: Diseases Of the Tongue And Systemic Diseases That May Be Ref...mentioning

confidence: 99%

Physiology of the tongue with emphasis on taste transduction

Doyle

Premathilake

Yao

et al. 2023

Physiological Reviews

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The tongue is a complex multifunctional organ that interacts and senses both interoceptively and exteroceptively. Although it is easily visible to almost all of us it is relatively understudied and what is in the literature as regards taste mechanisms is often contradictory or is not comprehensively reported. The tongue is both a motor and a sensory organ: motor in that it is required for speech and mastication, and sensory in that it receives information to be relayed to the central nervous system pertaining to the safety and quality of the contents of the oral cavity. Additionally, the tongue and its taste apparatus form part of an innate immune surveillance system. For example, loss or alteration in taste perception can be an early indication of infection as became evident during the present global SARS-CoV-2 pandemic. Here we particularly emphasize the latest updates in the mechanisms of taste perception, taste bud formation and adult taste bud renewal, the presence, and effects of hormones on taste perception, review the understudied lingual immune system with specific reference to SARS-CoV-2, discuss nascent work on tongue microbiome, as well as addressing the effect of systemic disease on tongue structure and function, especially in relation to taste.

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“…Secondary macroglossia is related to, or associated with, neoplastic processes, metabolic or endocrine disorders, or syndromic conditions [1][2][3][4]. Examples of underlying disease processes causing secondary macroglossia are vascular malformations (such as hemangioma or lymphangioma) and myxedema due to hypothyroidism [1,3]. Macroglossia can also occur secondary to amyloidosis [5].…”

Section: Introductionmentioning

confidence: 99%

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

Jenzer

2021

SJO

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Around 10-15% of patients with multiple myeloma develop amyloidosis due to the extracellular deposition of light-chain amyloid molecules. When this deposition occurs in the tongue, patients may exhibit macroglossia. The sequelae of this macroglossia can include dysphagia and gagging, tooth displacement, and airway compromise. This article presents the case of a 43-year-old African American female who was treated with a partial glossectomy secondary to amyloidosis related multiple myeloma.

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Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review

Cited by 7 publications

References 12 publications

Functional outcomes in children with reduction glossectomy for vascular malformations - "less is more!"

Functional outcomes in children with reduction glossectomy for vascular malformations - "less is more!"

Physiology of the tongue with emphasis on taste transduction

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

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