Unusual cardiac features in cholestatic hepatitis A in an adolescent: Improvement with corticosteroid treatment

Atabek, Mehmet Emre; Pirgon, Özgür

doi:10.1016/j.jinf.2006.05.001

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Studies in rodent models of liver injury and cholestasis,2–4 as well as clinical observations in patients with end-stage liver failure and cholestasis,5 6 found alterations in cardiac structure, function and electrical properties (‘cirrhotic cardiomyopathy’). Moreover, evidence concerning a particular form of cholestasis, intrahepatic cholestasis of pregnancy (ICP), which is a substantial cause for morbidity and mortality of the fetus,7 suggests that fetal arrhythmias are responsible for adverse outcomes 8–10.…”

Section: Introductionmentioning

confidence: 99%

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

Rainer

Primeßnig

Harenkamp

et al. 2013

Heart

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High TCA concentrations induce arrhythmias in adult human atria while ursodeoxycholic acid does not. AF is associated with higher serum levels of non-ursodeoxycholic bile acid conjugates and low levels of ursodeoxycholic acid conjugates. These data suggest that higher levels of toxic (arrhythmogenic) and low levels of protective bile acids create a milieu with a decreased arrhythmic threshold and thus may facilitate arrhythmic events.

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Section: Introductionmentioning

confidence: 99%

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

Rainer

Primeßnig

Harenkamp

et al. 2013

Heart

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“…Vaboe et al described combination of interstitial nephritis and ATN associated nonfulminant hepatitis A requiring dialysis support 8. Also viral hepatitis A has been rarely associated with cardiac manifestations9 and pancreatitis 10. We could not find any such case with combination of renal, cardiac, and pancreatic involvement associated with viral hepatitis A in the literature.…”

Section: Discussionmentioning

confidence: 65%

Acute renal failure associated with nonfulminant acute viral hepatitis A

Sarawgi

Arora

et al. 2008

Indian J Nephrol

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“…Atabek et al presented a 16-year-old adolescent patient with acute HAV infection because of bradycardia, hypotension, and progressive cholestasis developed in the patient and emphasized that this association was the first pediatric presentation [10]. Indeed, in the literature, cardiac involvement of HAV has not been documented in large series but in sporadic cases; we have reviewed some (Table 2) [9][10][11][12][13]. There was no finding suggestive of myocarditis in our patient.…”

Section: Discussionmentioning

confidence: 99%

Transient sinus bradycardia caused by hepatitis A virus: a case report

Kilicaslan

İşançlı

Fil

et al. 2022

Egypt Pediatric Association Gaz

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Background The most common cause of acute viral hepatitis is the hepatitis A virus (HAV). Millions of people are thought to be infected each year. It is transmitted either by the fecal-oral route or by consuming contaminated food. Extrahepatic complications, notably cardiologic ones, are infrequent. This case report was presented due to the development of HAV-related bradycardia without hypotension in an unvaccinated refugee patient. Case presentation A 9-year-old male presented with the complaint of jaundice and vomiting. There was no history of fever, diarrhea, or abdominal pain. A precise knowledge of suspected food intake is lacking. There was no pathological examination finding except jaundice. Total bilirubin, direct bilirubin, aspartate aminotransferase, and alanine aminotransferase levels were high. The coagulation test was normal. Anti-HAV-IgM/IgG was positive in the patient with suspicious viral hepatitis. In the follow-up, the heart rate decreased to 43 beats/min during sleep and 46 beats/min when awake. Cardiological examination and tests were within normal limits. Hypotension was not accompanied. In the follow-up, bradycardia and impaired liver function tests regressed. The patient was discharged on the 10th day. Conclusions Cardiologic complications are rare, and patients diagnosed with acute hepatitis A should be monitored. The most effective way of protection from the hepatitis A virus is vaccination.

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Unusual cardiac features in cholestatic hepatitis A in an adolescent: Improvement with corticosteroid treatment

Cited by 6 publications

References 15 publications

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

Acute renal failure associated with nonfulminant acute viral hepatitis A

Transient sinus bradycardia caused by hepatitis A virus: a case report

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