Unusual Benign Paratesticular Tumor in an Infant Mimicking Rhabdomyosarcoma

Ruiz, Eduardo; Pozo, Patricio; Toselli, Luzia; Fernández, María Cecilia; Christiansen, Stefan; Lambertini, Roberto

doi:10.1016/j.urology.2007.12.030

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…366 A 17-month-old boy had a firm mass in the upper aspect of the left paratestis identified on physical examination. 367 A 4-mm nodule with a stone-like consistency was easily removed at operation and showed the characteristic features of a pilomatrixoma.…”

Section: Other Miscellaneous Paratesticular Neoplasmsmentioning

confidence: 99%

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Ulbright

Young

2014

Seminars in Diagnostic Pathology

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Section: Other Miscellaneous Paratesticular Neoplasmsmentioning

confidence: 99%

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Ulbright

Young

2014

Seminars in Diagnostic Pathology

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“…Touton giant cells are illustrated in the latter case, but were not identified in the other 4 cases. This infant was the only one other than our case 3 who did not have an orchiectomy and was the only one to develop a recurrent scrotal mass 15 months after surgery [6]. It was elected to carefully follow this child, and the mass diminished in size when the child was 2.5 years of age; this reflects the potential for lesions of JXG to undergo spontaneous regression in some cases.…”

Section: Discussionmentioning

confidence: 98%

“…There are at least 2 well-documented cases of JXG presenting as a scrotal-testicular mass in infants [5,6] ( Table 3). A third putative case, which is not included in Table 3, is a 20-month-old boy with a 5-month history of a scrotal mass surrounding the testis, much like case 2, but the foamy histiocytes in a mixed inflammatory background should have raised the possibility of xanthogranulomatous periorchitis rather than JXG [30].…”

Section: Discussionmentioning

confidence: 99%

“…Only case 1 (Table 3) and our 3 cases were clearly intratesticular masses, but infiltration of the epididymis was present in 2 of our cases. The mass in the 6-month-old infant that was reported by Ruiz and associates [6] was described as a “friable and bloody mass” surrounding the testis and involving the epididymis. Touton giant cells are illustrated in the latter case, but were not identified in the other 4 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Although leukemic and lymphomatous involvement of the testis as a primary event is highly unusual in the first 2 years of life, the involvement of the testis by JXG can be mistaken for a hematolymphoid neoplasm. In the presence of an interstitial mononuclear infiltrative process with or without Touton giant cells in the testis of an infant or young child, it is important to consider the diagnosis of JXG whether or not there are other cutaneous or extracutaneous lesions as in our 3 cases and a fourth in the literature [6].…”

Section: Discussionmentioning

confidence: 99%

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Juvenile Xanthogranuloma Presenting as a Testicular Mass in Infancy: A Clinical and Pathologic Study of Three Cases

et al. 2010

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Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.

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