1995
DOI: 10.1080/10826079508010445
|View full text |Cite
|
Sign up to set email alerts
|

Unusual Analyte Adsorption Effects on Inert Lc Components

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
7
0

Year Published

1996
1996
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 12 publications
(7 citation statements)
references
References 3 publications
0
7
0
Order By: Relevance
“…Since higher water contents might even better mask residual silanol groups, both glass and bare silica were assumed to be inert in the set-up of our experiments. The use of columns, packed with small metal particles was also considered, although it is known that even stainless steel is not completely inert in all cases [27]. Since the packing of these columns was hampered by the high specific mass of the materials [22], in this respect only the use of a stainless steel pre-column filter was studied.…”
Section: Resultsmentioning
confidence: 99%
“…Since higher water contents might even better mask residual silanol groups, both glass and bare silica were assumed to be inert in the set-up of our experiments. The use of columns, packed with small metal particles was also considered, although it is known that even stainless steel is not completely inert in all cases [27]. Since the packing of these columns was hampered by the high specific mass of the materials [22], in this respect only the use of a stainless steel pre-column filter was studied.…”
Section: Resultsmentioning
confidence: 99%
“…have been found by other workers, especially when injecting the analyte in a solvent which was of lower eluting power than the HPLC mobile phase. [6][7][8][9][10][11] There was no clear identification of the adsorption site(s) in most of these studies, although Macleod et al 8 suspected that adsorption was taking place on the injector rotor valve seal.…”
Section: Problems Of Adsorption Of Single Compounds In Hplc Injectorsmentioning
confidence: 99%
“…Otero et al 9 thought that the stainless-steel sample loop was responsible, rather than the injector itself, and Hambleton et al 10 discovered that non-steroidal anti-inflammatory drugs (NSAIDs) were being adsorbed onto a polymeric PEEK™ sample loop. However, Lough et al, 11 although also finding evidence of analyte (Indomethacin) adsorption onto the surface of the stainless-steel sample loop, demonstrated by a series of elegant experiments that the major site of adsorption was the injector Vespel™ rotor seal.…”
Section: Problems Of Adsorption Of Single Compounds In Hplc Injectorsmentioning
confidence: 99%
“…165 However, even PEEK may exhibit problems with adsorption, as observed for instance during loop injection of nonsteroid antiinflammatory drugs. 175 In our experience, the material also suffers from fatigue after prolonged use with eluents containing high concentrations of acetonitrile, eventually leading to bursts. This may have prompted the recent introduction of gold-coated columns as a way of fighting protein adsorption.…”
Section: The Biocompatibility Issuementioning
confidence: 99%