Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors

Hilbe, Wolfgang; Nußbaumer, Walter; Bonatti, Hugo; Thaler, J.; Niederwieser, Dietger; Nachbaur, David

doi:10.1038/sj.bmt.1702581

Cited by 20 publications

(11 citation statements)

References 25 publications

(18 reference statements)

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“…The shortterm clinical adverse side effects are well known, and most frequently described as mild to moderate, 6 although isolated cases of severe clinical involvement have been published. [7][8][9] The long-term safety of the G-CSF use in healthy donors is however not well documented and to date few results are available. [10][11][12] In view of this, additional data are needed to exclude long-term bone marrow damage.…”

Section: Adverse Side Effectsmentioning

confidence: 99%

Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study

Tassi¹,

Tazzari²,

Bonifazi

et al. 2005

Bone Marrow Transplant

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Summary:Healthy allogeneic donors, who were treated with G-CSF and underwent peripheral blood haematopoietic precursor collection at our Institution, were enrolled in a short-and long-term haematological surveillance protocol for a 5-7-year period. To date, 94 donors have been assessed with a mean follow-up of 30 months (4-84); for 30 subjects, the follow-up is X48 months. During G-CSF administration, 23/94 donors showed a significant platelet count decrease from the baseline. Pre-apheresis platelet decrement correlated with the total G-CSF dose administered, baseline platelet level and donor age. Normal platelet counts returned within 4-8 months. PMN and/or lymphocyte lower values were observed in 55/94 donors 2 weeks after G-CSF administration, with mean drops from the baseline of 40 and 36% for PMN and lymphocytes, respectively. The PMN decrease correlated inversely with donor age, as younger donors were more affected than older ones, whereas the lymphocyte decrease correlated directly with the total blood volumes processed in the apheresis courses, in particular for donors subjected to large volume leukaphereses. Long-term observation showed moderate neutrophil reduction (25% count drop from the baseline) in four of the 30 donors observed for four years or more. 14 donors showed persistent, slight lymphocytopenia (mean drop of 13%) until the third year, with recovery in the fourth year of follow-up.

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Section: Adverse Side Effectsmentioning

confidence: 99%

Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study

Tassi¹,

Tazzari²,

Bonifazi

et al. 2005

Bone Marrow Transplant

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Section: Toxicity During Cytokine Therapymentioning

confidence: 99%

“…Other side effects due to G-CSF are headache, splenomegaly, anemia, thrombocytopenia, hypersensitivity and urticarial at injection site [52,54]. G-CSF-also induced lung toxicity post cancer chemotherapy [55][56][57].GM-CSF treatment has greater frequency of side effects -most common being fever accompanied with influenza-like syndrome and myalgias [58]. Flushing, hypotension, tachycardia, dyspnea and musculoskeletal pain are the first dose reaction due to the GM-CSF administration.…”

mentioning

confidence: 99%

Cytokines and their Role in Health and Disease: A Brief Overview

Gulati¹,

Guhathakurta²,

Joshi³

et al. 2016

MOJI

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Cytokines are small, non-structural proteins with low molecular weights which have a complex regulatory influence on inflammation and immunity. It has long been considered that development of immune and inflammatory response involves hematopoietic cells, lymphoid cell, and various pro-inflammatory and anti-inflammatory cells, and cytokines mediate the complex interactions of these cells. Cytokines are the intercellular messengers in the immune system where they integrate function of several cell types in various body compartments into a coherent immune response. They have evolved over the years and now include the interferons, the interleukins, the chemokine family, mesenchymal growth factors, the tumor necrosis factor family and adipokines. Earlier known as `soluble factors`, cytokines are produced by and elicit a response from every cell, with the lone exception of the red blood cell. In response to various stimulus cytokines are secreted from various cells including white blood cells. Pleiotropism is the hallmark of a cytokine and there are failures and successes of cytokines and related agents as therapeutic agents. In the membrane of target cells they have specific receptors for their signal transduction and regulatory functions. Beyond the innate and adaptive immunity, cytokines has a major role in many diverse functions including immune cell differentiation, inflammation, angiogenesis, tumorigenesis, neurobiology, viral pathogenesis etc. In addition to inflammation, immunity and infections, cytokines have now expanded their domain to atherosclerosis and cancer. Thus, cytokines may be useful biomarkers for health and disease and act as diagnostic, prognostic and therapeutic agents. This review will highlight the impact of cytokines in various physiological actions, pathophysiological states, therapeutics and the complex interactions between brain and immune cells. knowledge has highlighted the complexity and biphasic nature of cytokines -and the same molecule may have beneficial as well as detrimental effects. For example, interferon-γ (IFNγ), which is essential for defense against several intracellular microorganism such as Mycobacterium tuberculosis, is also a major cytokine in the pathogenesis of several autoimmune diseases. IL-2 is needed for the generation of cytotoxic T-cells (CTL) and forms the basis for several vaccines but the same cytokine drives graft versus host disease and limits the success of bone marrow transplantation [5]. Keywords: Cytokine ReceptorsThe cytokines exert various biological effects through receptors present on the membranes of responsive target cells. These receptors have an extracellular domain, a cytoplasmic domain and a single membrane spanning domain. There is the presence of conserved amino acid sequence motifs on the extracellular domain and these motifs include four conserved cysteine residues. There is also the presence of two polypeptide chains. One is the cytokine specific α subunit and other is a signal transducing β subunit.The nature of the target cell ...

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“…Reversible side-effects like non-cardiac chest pain, minor local reactions at the injection site, insomnia, dizziness, and subfebrile temperatures were also reported. Severe side-effects as sweet syndrome, leukocytoclastic vasculitis, acute iritis, interstitial pneumonitis, adult respiratory distress syndrome (ARDS), pyoderma gangraenosum, capillary leakage, thromboembolic events, acute gouty arthritis, severe anaphylactoid reactions, cerebrovascular incidents, non-traumatic splenic rupture, and severe pyogenic infections were reported [25][26][27][28][29][30]. In a study about side-effects in unrelated donors of PBSC, female donors had higher rates of side-effects, requiring central line placement more often (p < 0.001), experiencing more apheresis related side-effects (P < 0.001), more bone pain.…”

Section: Side-effects Of G-csfmentioning

confidence: 97%