Untoward Effects of Vitamin B1

Leitner, Z. A.

doi:10.1016/s0140-6736(00)87491-7

Cited by 31 publications

(3 citation statements)

References 8 publications

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“…thiamine in 989 patients and found 'minor reactions' (burning at injection site) in 11 patients and one case of generalized pruritus, indicating that thiamine administration is generally safe. However, anaphylactic responses do occur occasionally when B vitamins are given orally, i.v., i.m., or s.c., but are most often seen after multiple administrations when given i.v., on 'the end of a needle', as opposed to by an infusion over 30 min (Laws, 1941;Schiff, 1941;Stiles, 1941;Leitner, 1943;Reingold and Webb, 1946;Assem, 1973;Stein and Morgenstern, 1994).…”

Section: Is There a Risk Of Anaphylaxis?mentioning

confidence: 99%

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Thomson¹

2002

Alcohol and Alcoholism

346

310

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The Royal College of Physicians (London) recently published its latest report on alcohol misuse entitled 'Alcohol - Can the NHS Afford It?'. Part of this document, encompassing our views, has made specific recommendations for the management of patients in the Accident and Emergency (A&E) Department who may possibly have, or are at risk of developing, Wernicke's encephalopathy. Patients showing evidence of chronic alcohol misuse and suspected of having a poor diet should be treated at the outset with B vitamins intravenously or intramuscularly, especially when the clinical signs are initially masked by drunkenness at presentation to the A&E Department. This commentary offers a review of the scientific foundations on which these recommendations have been made.

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Section: Is There a Risk Of Anaphylaxis?mentioning

confidence: 99%

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Thomson¹

2002

Alcohol and Alcoholism

346

310

View full text Add to dashboard Cite

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“…These include anaphylactic shock (rarely fatal), dyspnoea and bronchospasm and cutaneous rash or flushing (39,87). Because the unwanted side-effects to B vitamins are most commonly seen after multiple administrations when given intravenously, rather than a slow infusion (92,93). Thiamine should be given intravenously diluted with 100 mL of normal saline or 5% glucose, and infused over 30 min (39,87).…”

Section: Parenteral Thiamine and Unwanted Side-effectsmentioning

confidence: 99%

Alcohol Induced Neurocognitive Impairment (Wernicke - Korsakoff): A Hidden Syndrome

Dayal¹

2015

CMR

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Wernicke's encephalopathy (WE) is an acute neuro-psychiatric syndrome due to inadequate supply of thiamine (vitamin B1) to the brain which leads to significant morbidity and mortality. Although alcohol use is the most common predisposing factor but Wernicke's encephalopathy can occur in any patient with nutritional deficiency conditions such as hyperemesis gravidarum, hemodialysis, malignancy, use of total parenteral nutrition without adequate thiamine, and abdominal surgery. In a developing country, there are more chances of thiamine deficiency, because of poor intake of nutrients in routine diet due to economic reasons and local customs and cultural practices concerning the processing and cooking of rice and other foodstuffs. The national household survey of drug use in India (2004) found prevalence of alcohol use in about 21.4% of male population between 18-40 age group. Most of the emergency physicians and general practitioners are not well sensitized about neuropsychiatric disorders in patients with alcohol use disorders. Such patients are still under diagnosed. Till date, no such studies are available about treatment of wernicke-korsakoff syndrome in Indian population. Educating clinicians, specially emergency physicians about evaluation and treatment of Wernicke-Korsakoff syndrome is as important as to educate people to eat well balanced, mixed diet containing thiamine rich food as most of these patients receive emergency treatment but are frequently unrecognized. If undiagnosed or inadequately treated, it is likely to proceed to Korsakoff syndrome. Therefore best treatment for Wernicke-Korsakoff syndrome is prompt diagnosis and adequate treatment.

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“…neuromuscular paralysis. feelings of agitation and panic) have been documented (Haley & Flesher 1946;Leitner 1943;Eisenstadt 1942;Mills 1941;Stiles 1941). It is therefore prudent.…”

Section: Pharmacological Adjuncts For Sedative-hypnotic Withdrawalmentioning

confidence: 99%

Pharmacological Adjuncts for the Treatment of Withdrawal Syndromes

Sees

1991

Journal of Psychoactive Drugs

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Alternative explanations for symptoms that occur during the period of drug (medical or nonmedical) withdrawal are examined. These symptoms are not necessarily due to the discontinuation of the drug and should be considered when treating a patient for a withdrawal syndrome. The rationale behind treating withdrawal syndromes and criteria to consider for hospitalizing a patient during the withdrawal period are discussed. The main focus of this article is the appropriate use of prescription drugs for treating withdrawal syndromes. In addition, protocols of the Drug Detoxification, Rehabilitation, and Aftercare Project of the Haight Ashbury Free Clinics are reviewed in detail. Finally, information is provided on some potentially promising medications that are currently being investigated for the treatment of withdrawal.

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Untoward Effects of Vitamin B1

Cited by 31 publications

References 8 publications

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Alcohol Induced Neurocognitive Impairment (Wernicke - Korsakoff): A Hidden Syndrome

Pharmacological Adjuncts for the Treatment of Withdrawal Syndromes

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