Untersuchungen zur Wirkung verschiedener Diuretika und Aldosteronantagonisten auf die renale Magnesiumausscheidung

Diuretics

“…Since 60% of filtered magnesium is reabsorbed in the ascending limb of Henle's loop (QUAMME and DIRKS 1980), loop diuretics and thiazides increase urinary magnesium excretion (ABDELHAMID et al 1969) and may reduce body magnesium content in patients receiving long-term treatment (SHEEHAN and WHITE 1982). The incidence of hypomagnesemia during treatment with these diuretics may be less than 10% (LAAKE et al 1978).…”

“…Normal or decreased magnesium content was observed in muscle cells. This can be achieved with potassium-sparing diuretics which do not enhance magnesium excretion (ABDELHAMID et al 1969) (Fig. Prevention or correction of hypomagnesemia is therefore needed in these patients.…”

“…:::: .. -....... -...................Renal magnesium excretion after a single oral dose of mefruside, furosemide, ethacrynic acid, and triamterene as well as after a single intravenous dose of Kcanrenoate(ABDELHAMID et al 1969) excessive vasopressin secretion may contribute to this hyponatremia, which can also be observed in other clinical states associated with decreased effective plasma volume. :-.~,.--:.…”