Untersuchungen zur Maßstabsverkleinerung von Filtrationsprozessen

Jermann, Simon; Schreiner, Andreas; Schneeberger, Ricardo

doi:10.1002/cite.200800004

Cited by 3 publications

(3 citation statements)

References 6 publications

(1 reference statement)

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“…Durch die Kombination von UTP‐Mikrofiltration und nachgeschalteter Ultrafiltration konnten Proteine aus Molke effizienter abgetrennt werden als durch herkömmliche Crossflow‐Filtration. Weitere interessante Beiträge befassten sich mit Presselektrofiltration zur Bioseparation , der Ultrafiltration in der pharmazeutischen Industrie , der NADPH‐Herstellung im Enzym‐Membran‐Reaktor , Maßstabsverkleinerungen von Filtrationen und der Isolierung nativer Proteinfraktionen aus Kartoffelwasser mithilfe von Membranadsorbern . Einen interessanten Überblick zum Stand der Membrantechnik des beginnenden 21.…”

Section: Biotechnologie 1949 Bis Heuteunclassified

“…Einen neuen Schwerpunkt in der Berichterstattung in der CIT bilden insbesondere zu Beginn des Jahrzehnts Publikationen im Bereich der Säugerzellkultivierung. Während die in den 70er Jahren durch Köhler und Milstein [119] [128], der Ultrafiltration in der pharmazeutischen Industrie [129], der NADPH-Herstellung im Enzym-Membran-Reaktor [130], Maßstabsverkleinerungen von Filtrationen [131] und der Isolierung nativer Proteinfraktionen aus Kartoffelwasser mithilfe von Membranadsorbern [132]. Einen interessanten Ü berblick zum Stand der Membrantechnik des beginnenden 21.…”

Section: Introductionunclassified

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90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

Akermann

Bold

Mehring

et al. 2018

Chemie Ingenieur Technik

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90 Jahre Chemie Ingenieur Technik (CIT) spiegeln wesentliche Meilensteine der Entwicklung der Biotechnologie und Bioprozesstechnik wider. In diesem Artikel werden einige der wichtigsten Entwicklungen vorgestellt und die Ausbildung von Trends in der Bioverfahrenstechnik nachgezeichnet. Beim Lesen der älteren Artikel lässt sich feststellen, dass einige der aktuellen Forschungsgebiete durchaus nicht ganz so neu sind, sondern vielversprechende Ansätze auch früher schon bearbeitet wurden.

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Section: Biotechnologie 1949 Bis Heuteunclassified

Section: Introductionunclassified

90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

Akermann

Bold

Mehring

et al. 2018

Chemie Ingenieur Technik

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“…Two publications dealing with scaling effects during gas pressure‐driven cake filtration are known by the authors. Schreiner compared the filtration behavior of two pharmaceutical additives for three different filter areas. Pressure filters were used, which differed in wall material and filter plates though.…”

Section: Introductionmentioning

confidence: 99%

Downscaling cake filtration—Correlations between compressibility of lysozyme crystal filter cakes and filter area

Cornehl

Weinkötz

Nirschl

2013

Engineering in Life Sciences

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Research Article Downscaling cake filtration-Correlations between compressibility of lysozyme crystal filter cakes and filter areaCrystallization is a commonly used method for the purification and formulation of proteins. In order to harmonize crystallization with the mechanical separation process, it is necessary to estimate early the separation conditions of protein crystals. To fulfill this requirement, the feed material for filtration is minimized by reducing the filter area. The filtration behavior of lysozyme crystals in pressure filters with two different filter areas was compared. Crystal slurries with different mean crystal sizes and shapes were produced and the influence of the size and shape on the scalability of filtration data was examined. It was found that for different aggregated crystal structures and isometric crystals, the larger the compressibility of the cake was, the larger were the deviations for the two considered filter areas. For needle-shaped crystals, the compressibility was not subject to deviations, but the absolute filter cake resistance was. Furthermore, the deviations of the cake resistances increased with higher pressures for all product systems. It was indicated that upscaling from the small filter area is possible for low compressible product systems and at low pressures. With high compressible products and for needle-like crystals, the filtration time is underestimated with the small filter area.

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Influence of Wall Effects on Filter Upscaling during Solid‐Liquid Filter Tests

2016

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Industrial solid-liquid filtration units are upscaled based on laboratory tests, often by a resistance meter. Wall or boundary effects are more pronounced during lab tests compared with full-scale units where these effects might be negligible. Thus, simply using area-specific rates from lab tests may lead to a significant upscaling error. Intentional alterations of wall lengths and filtration areas are performed to allow quantitative description of this effect. Smaller area and longer wall length result in faster cake buildup as well as higher air consumption during subsequent cake drying. This indicates that the permeability close to the walls is different. Extrapolation towards negligible specific wall areas is used to improve upscaling calculations.

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Untersuchungen zur Maßstabsverkleinerung von Filtrationsprozessen

Cited by 3 publications

References 6 publications

90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

90 Years CIT – 90 Years Development in Biotechnology and Bioprocess Engineering

Downscaling cake filtration—Correlations between compressibility of lysozyme crystal filter cakes and filter area

Influence of Wall Effects on Filter Upscaling during Solid‐Liquid Filter Tests

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