Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen aus<i>Cimicifuga racemosa</i>

Jarry, H.; Harnischfeger, G.

doi:10.1055/s-2007-969390

Cited by 47 publications

(10 citation statements)

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“…However, in the following experiments, the side effects of the CR extracts were not observed. The same result was obtained on dichloromethane extract of CR in OVX rats [128]. Our experiment which is described later also confirmed that the EtOAc-soluble Hereto, the mechanism is still ambiguous.…”

Section: Anti Menopause Symptoms Effect: Clinical Trials and Possiblesupporting

confidence: 88%

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Publisher¹

2006

CMC

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Cimicifugae Rhizoma, mainly originated from C. acerina, C. dahurica, C. foetida, C. heracleifolia, C. racemosa and C. simplex, has long been used in traditional medicine system. During the past 45 years, a lot of efforts have been dedicated to the studies on their bioactive constituents, pharmacological effects and clinical uses, and a variety of biological activities including relief of hot flash, anti-osteoporosis, anti-human immunodeficiency virus (HIV), antiinflammatory, antidiabetes, antimalaria and vasoactive property have been discovered. Although C. racemosa is widely applied to relieve menopause symptoms in clinic for its hormonal-like action, meaningfully, no estrogenic effect was confirmed up to date. The purpose of this paper is to systematically highlight these achievements and the further therapeutic potential. The origins and distributions of the rhizome are simply listed and phytochemical aspects including over 200 compounds mainly belonging to cycloartane-type triterpenoids have been summarized. The pharmacological characterizations, especially, as a clinically effective phytomedicine, the effects of the rhizoma on menopause symptoms and the clinical applications including possible mechanism have been reviewed in detail. Various in vivo, in vitro studies on the anti-bone resorption effects of the triterpenoids, together with structure-activity relationships are also incorporated to explore the therapeutic potential on osteoporosis, a major public health threat for postmenopausal women.

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Section: Anti Menopause Symptoms Effect: Clinical Trials and Possiblesupporting

confidence: 88%

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Publisher¹

2006

CMC

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“…This was expected since BCE used in these studies did not contain detectable levels of formononetin, an estrogenic isoflavone reported in some black cohosh samples (Jarry et al 1985). Furthermore, the highest dose used seemed to delay puberty in rats by 3 days while a similar delay in B6C3F1/N mouse puberty attainment was not dose related; the observed delays in rodent pubertal attainment are not expected from an estrogenic compound but may be produced by chemicals that block estrogen or prevent its biosynthesis (Marty et al 1999).…”

Section: Discussionmentioning

confidence: 65%

“…BCE appears to reduce luteinizing hormone secretion in ovariectomized rats but not in perimenopausal women (Chung et al 2007; Jacobson et al 2001; Jarry and Harnischfeger 1985; Nappi et al 2005; Rachon et al 2008; Reame et al 2008; Seidlova-Wuttke et al 2003); demonstrations of estrogenic/anti-estrogenic activity of black cohosh are inconclusive (Jarry and Harnischfeger 1985; Jarry et al 2003). However, neurotransmitter activities that can modify activity of the hypothalamic-pituitary-gonadal (HPG) axis at the CNS level (reviewed by Rivier and Rivest 1991), including dopaminergic, serotonergic, and opioid activity, have been observed in vitro (Jarry et al 2003; Powell et al 2008; Rhyu et al 2006).…”

Section: Introductionmentioning

confidence: 99%

An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents

Mercado-Feliciano

Cora

Witt

et al. 2012

Toxicology and Applied Pharmacology

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Black cohosh rhizome (Actaea racemosa) is used as a remedy for pain and gynecological ailments; modern preparations are commonly sold as ethanolic extracts available as dietary supplements. Black cohosh was nominated to the National Toxicology Program (NTP) for toxicity testing due to its widespread use and lack of safety data. Several commercially available black cohosh extracts (BCE) were characterized by the NTP, and one with chemical composition closest to formulations available to consumers was used for all studies. Female B6C3F1/N mice and Wistar Han rats were given 0, 15 (rats only), 62.5 (mice only), 125, 250, 500, or 1000 mg/kg/day BCE by gavage for 90 days starting at weaning. BCE induced dose-dependent hematological changes consistent with a non-regenerative macrocytic anemia and increased frequencies of peripheral micronucleated red blood cells (RBC) in both species. Effects were more severe in mice, which had decreased RBC counts in all treatment groups and increased micronucleated RBC at doses above 125 mg/kg. Dose-dependent thymus and liver toxicity was observed in rats but not mice. No biologically significant effects were observed in other organs. Puberty was delayed 2.9 days at the highest treatment dose in rats; a similar magnitude delay in mice occurred in the 125 and 250 mg/kg groups but not at the higher doses. An additional uterotrophic assay conducted in mice exposed for 3 days to 0.001, 0.01, 0.1, 1, 10, 100 and 500 mg/kg found no estrogenic or anti-estrogenic activity. These are the first studies to observe adverse effects of BCE in rodents.

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“…Der Wurzelstock von Cimicifuga racemosa Nuttal (Ranunculaceae) dient als Ausgangsmaterial für Arzneimittelzubereitungen, die für eine Alternativtherapie zur Ostrogensubstitution bei menopausalen Beschwerden verwendet werden. Tierexperimentell konnte die endokrine Wirksamkeit des Drogenauszugs fiber eine selektive Reduktion der Serumkonzentration des Hypophysenhormons LH nachgewiesen werden (1).…”

Section: Introductionunclassified

Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen ausCimicifuga racemosa2.In vitro-Bindung von Inhaltsstoffen an Östrogenrezeptoren

1985

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The endocrine activity of compounds of the rhizome of CIMICIFUGA RACEMOSA can be demonstrated in the IN VIVO model of the ovariectomized rat as well as in the IN VITRO system of the estrogen receptor assay. A reduction of the serum levels of luteinizing hormone in ovariectomized rats takes place upon application of a methanol-extract. This extract contains substances, which are able to bind to estrogen receptors of rat uteri. Using the estrogen receptor assay as a pharmacological testsystem to determine the activity of different fractions, the chromatographic separation of the methanol-extract resulted in at least three different endocrine active compounds. One of these could be identified as the isoflavon Formononetine. The endocrine activity of this isoflavon was characterized in both described testsystems. It can be shown that Formononetine is a competitor in the estrogen receptor assay, but failed to reduce the serum levels of luteinizing hormone in overiectomized rats.

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Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen ausCimicifuga racemosa

Cited by 47 publications

References 3 publications

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes

An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents

Untersuchungen zur endokrinen Wirksamkeit von Inhaltsstoffen ausCimicifuga racemosa2.In vitro-Bindung von Inhaltsstoffen an Östrogenrezeptoren

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