Untersuchungen vermeintlicher und wirklicher Abflu�wege aus dem Subdural- und Subarachnoidealraum

Hoffmann, E.; Thiel, Walter

doi:10.1007/bf00537531

Cited by 12 publications

(2 citation statements)

References 10 publications

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“…Key and Retzius proposed that microscopic stomata were present between the endothelial cells of the dural sinus to allow the escape of the dye-filled fluid. Although criticized by later investigators for using high pressures for their injections which appeared to have led to rupture of the intervening membranes [ 30 , 31 ], the concept by Key and Retzius of a drainage of CSF to veins through these specialized structures was highly influential.…”

Section: Arachnoid Villi and Granulationsmentioning

confidence: 99%

“…This is unlikely, as the same objections could then be raised in reference to the many physiological studies demonstrating rapid bulk CSF outflow of macromolecules. However, one potential anatomical arrangement that could allow for an uninterrupted flow of CSF would be if the lymphatics directly adjoined to the perineural space, as proposed by Hoffman and Thiel [ 30 ] and by the more recent work of the group of Miles Johnston [ 83 , 124 ]. In this version of the model, a “collar” of lymphatics surrounding the olfactory nerve rootlet isolates the perineural space from the surrounding submucosal interstitial tissue.…”

Section: Outflow Along Cranial Nervesmentioning

confidence: 99%

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Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

Proulx

2021

Cell. Mol. Life Sci.

216

221

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Cerebrospinal fluid (CSF) is produced by the choroid plexuses within the ventricles of the brain and circulates through the subarachnoid space of the skull and spinal column to provide buoyancy to and maintain fluid homeostasis of the brain and spinal cord. The question of how CSF drains from the subarachnoid space has long puzzled scientists and clinicians. For many decades, it was believed that arachnoid villi or granulations, outcroppings of arachnoid tissue that project into the dural venous sinuses, served as the major outflow route. However, this concept has been increasingly challenged in recent years, as physiological and imaging evidence from several species has accumulated showing that tracers injected into the CSF can instead be found within lymphatic vessels draining from the cranium and spine. With the recent high-profile rediscovery of meningeal lymphatic vessels located in the dura mater, another debate has emerged regarding the exact anatomical pathway(s) for CSF to reach the lymphatic system, with one side favoring direct efflux to the dural lymphatic vessels within the skull and spinal column and another side advocating for pathways along exiting cranial and spinal nerves. In this review, a summary of the historical and contemporary evidence for the different outflow pathways will be presented, allowing the reader to gain further perspective on the recent advances in the field. An improved understanding of this fundamental physiological process may lead to novel therapeutic approaches for a wide range of neurological conditions, including hydrocephalus, neurodegeneration and multiple sclerosis.

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Section: Arachnoid Villi and Granulationsmentioning

confidence: 99%