Untersuchungen über Konstitution und Krankheitsdisposition

Kisskalt, Karl; Friedmann, Alexander

doi:10.1007/bf02216639

Cited by 14 publications

(2 citation statements)

References 7 publications

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“…Ginsburg and Weatherall, 1948), and the persistence of lead in the marrow is clearly interesting in relation to the mechanism by which lead produces anaemia. The present figures for the concentration in muscle are lower than those of Kisskalt and Friedmann (1914) and of Kehoe and Thamann (1933), even allowing for the difference in dosage: but when the small quantities of lead involved are considered, the differences are not striking nor surprising. In the central nervous system the discrepancies are larger.…”

Section: Methodscontrasting

confidence: 74%

“…DISCUSSION The distribution of lead in the untreated rabbits of this series showed no unexpected features. As has generally been found in rabbits (Kisskalt and Friedmann, 1914;Lomholt, 1924;Kehoe and Thamann, 1933), the excretion of lead, even after parenteral administration, was greater in the faeces than in the urine after the first day or two, and the combined excretion amounted to about half the total dose in three weeks. The rate of excretion roughly followed an exponential curve, and had reached a very low level at the end of these experiments.…”

Section: Methodssupporting

confidence: 64%

See 1 more Smart Citation

The Effects of Dimercaprol and Parathyroid Extract on the Subacute Distribution of Lead (Acetate) in Rabbits

Adam¹,

Ginsburg²,

Weatherall³

1949

British Journal of Pharmacology and Chemotherapy

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It has been shown that dimercaprol (2: 3-dimercaptopropanol, BAL) increases the excretion and alters the distribution of lead in rabbits when the dimercaprol is given less than twenty-four hours after intravenous administration of lead acetate (Ginsburg and Weatherall, 1948). This paper extends these observations to a later phase in the distribution of a single intravenous dose of lead. At this phase most of the lead remaining in the body was found in the bones. It seemed likely that dimercaprol would not have much effect on lead so deposited, and, at the suggestion of Professor J. H. Gaddum, the effect of parathyroid extract, which is believed to mobilize lead from bones (Hunter and Aub, 1927), was also examined, alone and in conjunction with dimercaprol. METHODSThe procedure in these experiments followed that of Ginsburg and Weatherall (1948) with some modifications, as follows: Pb2"0 (radium D) was used as a tracer instead of Pb212 (thorium B), the short halflife of which made it useless for the present purpose. Radium E and radium F were removed from an equilibrium mixture of radium D, E, and F by displacement with nickel, added as foil to a solution in hydrochloric acid. A small quantity of the resulting solution of radium D and some dextrose were added to a solution of lead acetate so that the final solution contained 2.07 mg. Pb and 2-3 microcuries of radium D per ml. in 4 per cent (w/v) dextrose. Doses of 1.0 ml./kg. (i.e., 0.01 mM/kg.) were administered to rabbits of both sexes and various breeds by injection into the marginal vein of one ear at a rate of 2.0 ml. per min. After injection the rabbits were placed in metabolism cages and allowed food and water ad libitum ftbm vessels placed outside windows in the cages so that spilt food or water did not dilute

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Section: Methodscontrasting

confidence: 74%

Section: Methodssupporting

confidence: 64%