Untersuchungen über die Vererbung der Alkaloidarmut und die Variabilität des Restalkaloidgehaltes beiLupinus albus L.

Porsche, W.

doi:10.1007/bf00705826

Cited by 4 publications

(5 citation statements)

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“…It was suggested that functions of iucundus and pauper genes may be distinct because these species have different lysine profiles among wild and sweet accessions (Frick et al 2017). As expected, negative LAGI01_35805_F1_R1 scores were obtained for four low alkaloid lines carrying exiguus gene (95422 “Start”, 95480 “Nelly”, 95513 “Butan” derived from Start × Wat, 95454 “Tombowskij Skorospielyj”) and one carrying nutricius gene (95509 “Nahrquell”) (Hackbarth 1957; Hackbarth 1961; Harrison and Williams 1982; Porsche 1964; Šatović 1993; Troll 1958; Stawiński S. unpublished). Additionally, negative LAGI01_35805_F1_R1 scores were revealed for six sweet lines with unknown low-alkaloid donor (95175 “R-84141”, 95433 “Dniepr”, 95160 “R-243”, 95166 “SF-479”, 95445 “Lutrop,” and 95449 “Buttercup”).…”

Section: Discussionsupporting

confidence: 74%

“…Validation set of lines contained 127 bitter and five pauper (Kiev Mutant, Boros, Lotos, Hansa, Kali), four exiguus (Start, Nelly USA, Butan, Tombowskij Skorospielyj), one nutricius (Nahrquell), and sixteen other sweet or intermediate accessions with unknown genotype according to the information obtained from the Plant Breeding Smolice Ltd., Co. (Dr. Stanisław Stawiński) and published data (Hackbarth 1957; Hackbarth 1961; Harrison and Williams 1982; Kroc et al 2017; Porsche 1964; Šatović 1993; Troll 1958). Visualization of marker polymorphism for selected lines is provided in Supplementary File 3.…”

Section: Resultsmentioning

confidence: 99%

“…Genetic studies involving L. albus germplasm resulted in the identification of several loci underlying low alkaloid content: pauper / primus / tercius , exiguus , nutricius , mitis , suavis , reductus , and minutus (Hackbarth 1957; Hackbarth 1961; Harrison and Williams 1982; Porsche 1964; Šatović 1993; Troll 1958). Pauper was widely exploited for breeding; exiguus and nutricius were used occasionally, whereas other loci remained untapped (Harrison and Williams 1982; Šatović 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, during the domestication process, numerous efforts aiming at the reduction of alkaloid levels were strongly emphasized. As many as nine hypothetical loci controlling low alkaloid content were initially identified throughout white lupin breeding, including pauper , primus , tercius , exiguus , nutricius , mitis , suavis , reductus , and minutus (Hackbarth 1957; Hackbarth 1961; Porsche 1964; Šatović 1993; Troll 1958). However, primus and tercius were identified as the synonyms of pauper , whereas suavis and minutus were not studied as extensively as the other loci and their independence cannot be authenticated (Harrison and Williams 1982).…”

Section: Introductionmentioning

confidence: 99%

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Development of gene-based molecular markers tagging low alkaloid pauper locus in white lupin (Lupinus albus L.)

Rychel

Książkiewicz

2019

J Appl Genetics

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White lupin (Lupinus albus L.) is a legume grain crop cultivated since ancient Greece and Egypt. Modern white lupin cultivars are appreciated as a source of protein with positive nutraceutical impact. However, white lupins produce anti-nutritional compounds, quinolizidine alkaloids, which provide bitter taste and have a negative influence on human health. During domestication of this species, several recessive alleles at unlinked loci controlling low alkaloid content were selected. One of these loci, pauper, was exploited worldwide providing numerous low-alkaloid cultivars. However, molecular tracking of pauper has been hampered due to the lack of diagnostic markers. In the present study, the synteny-based approach was harnessed to target pauper locus. Single-nucleotide polymorphisms flanking pauper locus on white lupin linkage map as well as candidate gene sequences elucidated from the narrow-leafed lupin (L. angustifolius L.) chromosome segment syntenic to the pauper linkage group region were transformed to PCR-based molecular markers. These markers were analyzed both in the mapping population and world germplasm collection. From fourteen markers screened, eleven were localized at a distance below 1.5 cM from this locus, including five co-segregating with pauper. The linkage of these markers was confirmed by high LOD values (up to 58.4). Validation performed in the set of 127 bitter and 23 sweet accessions evidenced high applicability of one marker, LAGI01_35805_F1_R1, for pauper locus selection, highlighted by the low ratio of false-positive scores (2.5%). LAGI01_35805 represents a homolog of L. angustifolius acyltransferase-like (LaAT) gene which might hypothetically participate in the alkaloid biosynthesis process in lupins.Electronic supplementary materialThe online version of this article (10.1007/s13353-019-00508-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of gene-based molecular markers tagging low alkaloid pauper locus in white lupin (Lupinus albus L.)

Rychel

Książkiewicz

2019

J Appl Genetics

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“…Recessive low-alkaloid mutations in L. albus have also been identified: pauper, mitis, reductus, exiguus, and nutricius (Hackbarth, 1957;Troll, 1958;Porsche, 1964). As in the case of L. angustifolius, one locus, pauper, is the most studied in L. albus (Rychel and Książkiewicz, 2019).…”

Section: Defense-related Traitsmentioning

confidence: 99%

The Effects of Domestication on Secondary Metabolite Composition in Legumes

Contador

et al. 2020

Front. Genet.

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Legumes are rich in secondary metabolites, such as polyphenols, alkaloids, and saponins, which are important defense compounds to protect the plant against herbivores and pathogens, and act as signaling molecules between the plant and its biotic environment. Legume-sourced secondary metabolites are well known for their potential benefits to human health as pharmaceuticals and nutraceuticals. During domestication, the color, smell, and taste of crop plants have been the focus of artificial selection by breeders. Since these agronomic traits are regulated by secondary metabolites, the basis behind the genomic evolution was the selection of the secondary metabolite composition. In this review, we will discuss the classification, occurrence, and health benefits of secondary metabolites in legumes. The differences in their profiles between wild legumes and their cultivated counterparts will be investigated to trace the possible effects of domestication on secondary metabolite compositions, and the advantages and drawbacks of such modifications. The changes in secondary metabolite contents will also be discussed at the genetic level to examine the genes responsible for determining the secondary metabolite composition that might have been lost due to domestication. Understanding these genes would enable breeding programs and metabolic engineering to produce legume varieties with favorable secondary metabolite profiles for facilitating adaptations to a changing climate, promoting beneficial interactions with biotic factors, and enhancing health-beneficial secondary metabolite contents for human consumption.

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Genetic Control of Alkaloid Production

Waller

Nowacki

1978

Alkaloid Biology and Metabolism in Plants

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Untersuchungen über die Vererbung der Alkaloidarmut und die Variabilität des Restalkaloidgehaltes beiLupinus albus L.

Cited by 4 publications

References 5 publications

Development of gene-based molecular markers tagging low alkaloid pauper locus in white lupin (Lupinus albus L.)

Development of gene-based molecular markers tagging low alkaloid pauper locus in white lupin (Lupinus albus L.)

The Effects of Domestication on Secondary Metabolite Composition in Legumes

Genetic Control of Alkaloid Production

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