Untersuchungen über die Persistenz von Spirochaeta duttoni in Mäusegehirnen bei experimenteller Febris recurrens

Beunders, B. J. W.; Thiel, P. H. Van

doi:10.1007/bf02178007

Cited by 4 publications

(1 citation statement)

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“…The different periods of time spent feeding by soft and hard ticks (minutes versus days, respectively) clearly separates the biology of transmission of RF Borrelia and LD Borrelia. Under these very restricted time periods of transmission, a single spirochete may be enough to initiate an RF infection in experimental animals (Beunders and Van Thiel, 1932;Schuhardt and Wilkerson, 1951;Stoenner et al, 1982). The bacteria multiply in the blood at an estimated rate of one cell division every ~6 hours until they number between 10 6 to 10 7 , sometimes as many as 10 8 , per milliliter of blood at their peak (Figure 2) (Cadavid et al, 1994;Crowder et al, 2016;Schuhardt and Wilkerson, 1951;Stoenner et al, 1982).…”

Section: Mammalian Infection: Rf Borrelia Pathogenesismentioning

confidence: 99%

Pathogenesis of Relapsing Fever

López¹,

Hovius²,

Bergström³

2022

Current Issues in Molecular Biology

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Relapsing fever (RF) is caused by several species of Borrelia; all, except two species, are transmitted to humans by soft (argasid) ticks. The species B. recurrentis is transmitted from one human to another by the body louse, while B. miyamotoi is vectored by hard-bodied ixodid tick species. RF Borrelia have several pathogenic features that facilitate invasion and dissemination in the infected host. In this article we discuss the dynamics of vector acquisition and subsequent transmission of RF Borrelia to their vertebrate hosts. We also review taxonomic challenges for RF Borrelia as new species have been isolated throughout the globe. Moreover, aspects of pathogenesis including symptomology, neurotropism, erythrocyte and platelet adhesion are discussed. We expound on RF Borrelia evasion strategies for innate and adaptive immunity, focusing on the most fundamental pathogenetic attributes, multiphasic antigenic variation. Lastly, we review new and emerging species of RF Borrelia and discuss future directions for this global disease.The definite cause of RF was not established until 1868 when the German scientist Otto Obermeier caister.com/cimb 519 Curr.

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Section: Mammalian Infection: Rf Borrelia Pathogenesismentioning

confidence: 99%

Pathogenesis of Relapsing Fever

López¹,

Hovius²,

Bergström³

2022

Current Issues in Molecular Biology

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Morphologie und Biologie der Spirochäten. Experimentelle Syphilis

Ehrmann¹

1962

Syphilis Und Ulcus Molle

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Experimental Infection of the Mouse Brain by a Relapsing Fever Borrelia Species: A Molecular Analysis

Cadavid

Bundoc

Barbour

1993

The Journal of Infectious Diseases

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The spirochetal disease relapsing fever is notable not only for multiphasic antigenic variation but also for central neurologic manifestations. To further characterize involvement of the brain in this disorder, immunocompetent and -deficient mice were infected with Borrelia hermsii. Immunodeficient mice were treated while spirochetemic with neutralizing IgM monoclonal antibodies to the infecting serotype. Blood, cerebrospinal fluid, and brain tissue were examined by culture and polymerase chain reaction. In immunocompetent mice, antigenic variation occurred in the brain as well as in the blood. In immunodeficient mice, the infecting serotype was still present in the brain after it had been eliminated from the blood by the administered antibodies. These latter results cannot be accounted for by contamination of brain tissue and cerebrospinal fluid by blood and, hence, establish the direct involvement of the central nervous system in this experimental infection.

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Untersuchungen über die Persistenz von Spirochaeta duttoni in Mäusegehirnen bei experimenteller Febris recurrens

Cited by 4 publications

References 1 publication

Pathogenesis of Relapsing Fever

Pathogenesis of Relapsing Fever

Morphologie und Biologie der Spirochäten. Experimentelle Syphilis

Experimental Infection of the Mouse Brain by a Relapsing Fever Borrelia Species: A Molecular Analysis

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