Untersuchungen über die exokrine und endokrine Pankreasfunktion nach exogener und endogener Stimulation mit Secretin sowie Pentagastrin

Kaess, H; Schlierf, G.

doi:10.1007/978-3-642-47083-7_43

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…IRS significantly rose at 5' and 10' (p < 0.05 and < 0.01 respectively), but IRI was unchanged dogenous secretin stimulates insulin release. Several workers have been unable to show this [20][21][22][23][24][25]. However, in patients with portocaval shunts, rises in peripheral IRI levels after acid can be detected [26] suggesting that the hepatic clearance of insulin may mask peripheral changes.…”

Section: Discussionmentioning

confidence: 99%

Secretin and insulin: Response to intraduodenal acid

et al. 1976

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Summary.Immunoreactive secretin (IRS) and immunoreactive insulin (IRI) levels were measured in humans and dogs following the intraduodenal instillation of hydrochloric acid. IRS levels rose after acid in both instances, but a concomitant rise in peripheral IRI levels was not noted. Premedication of the humans with Scopolamine prevented a rise of IRS in the human subjects. It is concluded that the endogenous release of IRS alone does not result in increased IRI levels in peripheral blood and that IRS release may be under vagal control.

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Section: Discussionmentioning

confidence: 99%

Secretin and insulin: Response to intraduodenal acid

et al. 1976

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“…Concerning the action of gastrin on insulin secretion, stimulation (6-11), no effect (12)(13)(14)(15)(16), as well as inhibition (17) have been reported. The conflicting results may in part be due to the use of pharmacological doses of crude preparations or fragments of gastrin.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Gastrin on Basal- and Glucose-Stimulated Insulin Secretion in Man

Rehfeld¹,

Stadil²

1973

J. Clin. Invest.

157

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A B S T R A C T The effect of gastrin on basal-and glucose-stimulated insulin secretion was studied in 32 normal, young subjects. The concentration of gastrin and insulin in serum was measured radioimmunochemically.Maximal physiologic limit for the concentration of gastrin in serum was of the order of 160 pmol per liter as observed during a protein-rich meal. Oral ingestion of 50 g glucose produced a small gastrin response from 28±3 to 39+5 pmol per liter (mean +SEM, P < 0.01).Intravenous injection or prolonged infusion of gastrin increased the concentration of insulin in peripheral venous blood to a maximum within 2 min followed by a decline to basal levels after a further 10 min. The The results indicate that gastrin can stimulate a rapid and short-lived release of insulin. In physiologic concentrations gastrin potentiates the glucose-stimulated insulin secretion and is without effect on basal insulin secretion. A small release of gastrin during oral glucose ingestion may to a limited extent contribute to the nonglycemic insulin secretion. During protein ingestion, gastrin probably stimulates insulin secretion significantly.This work was presented in part at the International Symposium on "The impact of insulin on metabolic pathways," 26 October 1971, Jerusalem, Israel.

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