Untersuchungen über den Histamingehalt des Blutes bei Infusion von Adrenalin und Histamin

Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs

“…That adrenaline may act as a histamine releaser was also reported by EICHLr~R and BARFUSS [27], who found a rise in the plasma histamine levels during intravenous histamine infusion in the cat. In normal and pathological human subjects, increased plasma histamine levels were detected during intravenous infusions of adrenaline [28,29].…”

Factors influencing the urinary excretion of histamine in the rat

“…The doses of adrenaline used were large when compared with those used by some of the other workers (Mongar & Whelan, 1953;Staub, 1946;Koch & Szerb, 1950;Eichler & Barfuss, 1940), who, however, gave adrenaline by continuous infusion. It appears that, even if in the intact animal and in high doses, adrenaline causes a release of histamine, it is not a liberator of histamine under physiological conditions.…”

“…Both these factors would increase the chance of detecting histamine release in the intact animal by a weak liberator which also had other actions including that of vasoconstriction. It is possible that Eichler & Barfuss (1940) observed the prolonged release of histamine in the cat for the same reason. This may explain why Mongar & Whelan (1953) did not observe a physiological release of histamine with smaller doses in the human being.…”

Recent Studies on the Centrally Active Endogenous Amines

“…The release of catecholamines by tyramine is well documented. Tryptamine releases serotonin [105], histamine releases catecholamines 13141, and is itself released by epinephrine [315] and serotonin [316]. A metabolite of dopamine, 2,4,5-trihydroxyphenethylamine [8] is quite active as a releasing agent for norepinephrine in heart [317].…”