Untersuchungen der Verteilung von radioaktivem Urografin im menschlichen Organismus

Comparison of the Renal Excretion of I131‐labelled Diodrast, I131‐labelled Hypaque and Inulin

“…Diodrast, which has been used since the thirties in the assessment of renal function and of renal blood flow, has proved less suitable for external measurement (radioactive renogram), because it is also taken up by liver (Taplin et al 1956); consequently the radioactivity of this organ influences the right renal curve, which is then not strictly comparable with the left renal curve. Schlungbaum & Billion (1956) studied the renal excretion and distribution in man of a labelled triiodobenzoate, Plabelled Urografin. In a comparative study of inter alia this substance, Plabelled Hypaque, and IlS1-labelled Diodrast by the external measuring technique, Winter & Taplin (1958) showed that Ilsl-labelled Hypaque did not appear to accumulate in the region Submitted for publication January 27, 1961. of the liver.…”

“…Investigations on animals and human beings (Langecker et al 1954, Kimbel & Borner 1955, Schlungbaum & Billion 1956, Harrow 1956, McChesney & Hoppe 1957 have yielded only incomplete and contradictory results regarding the excretion of Hypaque. Our own investigations (Denneberg et al 1960) on cats showed, among other points, that the excretion of Hypaque by the kidneys was delayed compared with that of Diodrast.…”