Untersuchungen �ber den Mechanismus der Blutdruckwirkung des Anaphylatoxins bei Katzen und Meerschweinchen

Bodammer, G.

doi:10.1007/bf00537660

Cited by 7 publications

(1 citation statement)

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“…This suggestion is supported by the demonstration of a complete tachyphylaxis to the anaphylactic agent and to AT in both isolated guinea pig lungs and intact dogs-though under conditions of tachyphylaxis to one of the two agents, a full shock response could be sustained by the other agent. The presently observed effects of AT on the pulmonary and systemic circulations are similar to findings of Bodammer (1969) in the guinea pig and cat. Bodammer concluded that these effects of AT are direct and not mediated by released histamine or prostaglandins.…”

Section: Discussionsupporting

confidence: 84%

Anaphylatoxin‐induced shock and two patterns of anaphylactic shock: Hemodynamics and mediators*

Pávek

Piper

Smedegård

1979

Acta Physiologica Scandinavica

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In the dog, different cardiorespiratory reactions were identified in two types of anaphylactic shock and in C5a-AT (anaphylatoxin)-induced shock. All three types had in common a portal blood pooling with consequent decrease in the venous return, cardiac output, and arterial pressure. In anaphylaxis (a) of the first type, at a low titer of hemagglutinating antibodies, the latent period was 68 s and heart and lung function was unchanged. In the second type, at high titer, the latency was 19 s and pulmonary hypertension and decreased heart contractility occurred. After AT injection pulmonary hypertension appeared with tachypnea and unchanged heart function. Tachyphylaxis, but not cross-over tachyphylaxis against the anaphylactic agent and AT was observed in dogs and isolated guinea pig lungs. AT induced a transient release and a, a prolonged release of histamine, prostaglandins (PGs), and thromboxane A2 and endoperoxides from guinea pig lungs. SRS-A was released only in a. Indomethacin inhibited AT-induced release of PGs in guinea-pig lungs and AT-induced hypotension in the dog though it did not prevent the drop in cardiac output. These model studies suggest that different patterns of clinical a. can occur, depending on the type of antibodies and/or mediators involved.

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Section: Discussionsupporting

confidence: 84%