Untersuchungen �ber den Fettstoffwechsel bei der Fettsucht

Abstract

Serum levels of non-esterified fatty acids, free glycerol and esterified fatty acids were estimated in obese patients and in persons of normal weight after intravenous administration of tolbutamide and glucose. In obesity non-esterified fatty acids and glycerol levels were roughly twice as high as in the non-obese, whereas no difference in levels of esterified fatty acids was found between the two groups. Following administration of tolbutamide or glucose, there was a decrease of concentration of non-esterified fatty acids and glycerol to a minimum during the two hours of observation. In obesity, non-esterified fatty acids and glycerol decreased relatively more than in persons of normal weight. This behaviour is interpreted as due to increased insulin secretion in obesity. The difference in changes in concentration of non-esterified fatty acids and glyoerol in response to a variety of test situations may well be the result of both the glucose-dependent lipogenetic and the glucose-independent antilipolytic effect of insulin. The antilipolytic effect of insulin is discussed with reference to the metabolic aspects of obesity.

CHLORPROPAMIDE AND LIPID METABOLISM OF RAT AND HUMAN ADIPOSE TISSUE IN VITRO1

“…Acute administration of sulfonylurea compounds, such as tolbutamide and chlorpropamide, produces in non-diabetic subjects and in patients with maturity-onset diabetes mellitus a prompt fall in the plasma levels of FFA (2, 3, 4, 6) and glycerol (3). These effects have been attributed to a decrease in the lipid mobilization from adipose tissue due to insulin released by the direct action of the drugs on the /?-cells of the pancreas.…”

Asymptomatischer Diabetes mellitus bei normalgewichtigen Hypertonikern

“…zweite blutdruckwirksame Hormon der Nebennierenrinde ist das Aldosteron. Conn und Mitarbeiter(10,11) konnten in systematischen Untersuchungen der letzten Jahre feststellen, daß in 25°/o aller Fälle mit einer sogenannten essentiellen Hypertonie ein Aldosteronismus vorliegt.Dabei ist von Bedeutung, daß das Serum-Kalium nicht erniedrigt sein muß. Wiederum die Hälfte seiner Patienten mit einem Aldosteronismus wies eine verminderte Glucosetoleranz auf, die sich nach erfolgreicher Operation normalisierte.…”