Untersuchungen �ber den Feinbau von Spinalganglien

Kh, Andres

doi:10.1007/bf00319327

Cited by 297 publications

(115 citation statements)

References 71 publications

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“…Substance P and somatostatin are stored in different cells with similar morphology and together they comprise about 25% of all sensory ganglion cells . It is evident that both substance P and somatostatin as well as BN-GRP-LI are contained in small ganglion cells, classified as B cells by Andres (1961). Vasoactive intestinal peptide can be found in both small and large cells (Lundberg et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons

Panula¹,

Hadjiconstantinou²,

Yang³

et al. 1983

J. Neurosci.

146

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The existence of bombesin/gastrin-releasing peptide-like immunoreactivity (BN-GRP-LI) in rat sensory ganglia and spinal cord was confirmed using immunocytochemistry, gel filtration chromatography, and high performance liquid chromatography combined with radioimmunoassay. Immunohistochemical studies showed that in the spinal sensory ganglia of the rat about 5% of the neurons exhibited BN-GRP-LI, whereas about 20% of the neurons exhibited substance P-like immunoreactivity (SP-LI). The two immunoreactivities were found in different cells, but both were located in small ganglion cells. In the posterior horn of the spinal cord, BN-GRP-LI and SP-LI were located in the superficial layers, and this distribution was different from that of Met5-enkephalin-like immunoreactivity.The results are in agreement with the concept that there is a primary sensory pathway from the sensory ganglia to the spinal cord which contains BN-GRP-LI and that these neurons are separate from those containing substance P. In extracts prepared from spinal ganglia, two molecular weight forms of BN-GRP-LI were found using gel filtration chromatography. The high molecular weight form coeluted with porcine GRP and the low molecular weight form was smaller than bombesin. The low molecular weight BN-GRP-LI extracted from spinal cord was more hydrophilic than bombesin or ranatensin.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons

Panula¹,

Hadjiconstantinou²,

Yang³

et al. 1983

J. Neurosci.

146

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“…Neurons were classified into the two basic types already described (Andres, 1961;Lagares and Avendaño, 2000): A-type cells are large and contain small-to medium-sized clumps of Nissl substance that are more abundant in the central portions of the cytoplasm and are sparser in the periphery. They display a prominent and heavily stained nucleolus centrally located within a large and lightly stained nucleus.…”

Section: Quantitative Studies In Adult Rat Tg In Vivomentioning

confidence: 99%

Primary Sensory Neuron Addition in the Adult Rat Trigeminal Ganglion: Evidence for Neural Crest Glio-Neuronal Precursor Maturation

Lagares¹,

Li²,

Zhou³

et al. 2007

J. Neurosci.

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It is debated whether primary sensory neurons of the dorsal root ganglia increase the number in adult animals and, if so, whether the increase is attributable to postnatal neurogenesis or maturation of dormant, postmitotic precursors. Similar studies are lacking in the trigeminal ganglion (TG). Here we demonstrate by stereological methods that the number of neurons in the TG of adult male rats nearly doubles between the third and eighth months of age. The increase is mainly attributable to the addition of small, B-type neurons, with a smaller contribution of large, A-neurons. We looked for possible proliferative or maturation mechanisms that could explain this dramatic postnatal expansion in neuron number, using bromodeoxyuridine (BrdU) labeling, immunocytochemistry for neural precursor cell antigens, retrograde tracing identification of peripherally projecting neurons, and in vitro isolation of precursor cells from adult TG explant cultures. Cell proliferation identified months after an extended BrdU administration was sparse and essentially corresponded to glial cells. No BrdU-labeled cell took up the peripherally injected tracer, and only a negligible number coexpressed BrdU and the pan-neuronal tracer neuron-specific enolase. In contrast, a population of cells not recognizable as mature neurons in the TG and neighboring nerve expressed neuronal precursor antigens, and neural crest glioneuronal precursor cells were successfully isolated from adult TG explants. Our data suggest that a protracted maturation process persists in the TG that can be responsible for the neuronal addition found in the adult rat.

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“…Further light microscopy classification based on cell diameter size and the distribution and structure of Nissl bodies identified up to seven types of cell bodies (Clark 1926). Two major classes of neurons, with large and light or small and dark cell bodies, can also be observed in the electron microscope (Andres 1961;Lawson 1979;Lawson et al 1984). Andres (1961) further subdivided each group (which he termed Type A and Type B) into subtypes (A1, A2, etc.…”

Section: Classifying Drg Neurons Based On Cell Sizementioning

confidence: 99%

“…Two major classes of neurons, with large and light or small and dark cell bodies, can also be observed in the electron microscope (Andres 1961;Lawson 1979;Lawson et al 1984). Andres (1961) further subdivided each group (which he termed Type A and Type B) into subtypes (A1, A2, etc. ), resulting in six populations with overlapping cell diameter ranges.…”

Section: Classifying Drg Neurons Based On Cell Sizementioning

confidence: 99%

Morphological and functional diversity of first-order somatosensory neurons

2017

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First-order somatosensory neurons transduce and convey information about the external or internal environment of the body to the central nervous system. They are pseudo unipolar neurons with cell bodies residing in one of several ganglia located near the central nervous system, with the short branch of the axon connecting to the spinal cord or the brain stem and the long branch extending towards the peripheral organ they innervate. Besides their sensory transducer and conductive role, somatosensory neurons also have trophic functions in the tissue they innervate and participate in local reflexes in the periphery. The cell bodies of these neurons are remarkably diverse in terms of size, molecular constitution, and electrophysiological properties. These parameters have provided criteria for classification that have proved useful to establish and study their functions. In this review, we discuss ways to measure and classify populations of neurons based on their size and action potential firing pattern. We also discuss attempts to relate the different populations to specific sensory modalities.

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Untersuchungen �ber den Feinbau von Spinalganglien

Cited by 297 publications

References 71 publications

Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons

Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons

Primary Sensory Neuron Addition in the Adult Rat Trigeminal Ganglion: Evidence for Neural Crest Glio-Neuronal Precursor Maturation

Morphological and functional diversity of first-order somatosensory neurons

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