Untersuchung über den Einfluß von Cortison auf den Ablauf von Antigen-Antikörper- und Autoantikörper-reaktionen

Steffen, C; Fessl, Friederike; Schindler, H.

doi:10.1159/000205220

Cited by 8 publications

(2 citation statements)

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“…group. But corticosteroid itself does not influence the specific antigen-antibody reaction (18). From the above-mentioned facts this decrease of immune deposits in the skin, which was observed at 30 minutes after the induction may be considered to be due to the decrease of antigen influx from the blood into the tissue as a result of the inhibitory effect of dexamethasone upon the increased vascular permeability.…”

Section: Discussionmentioning

confidence: 90%

Immune Deposits in the Skin of Reversed Passive Arthus Reaction. The Effects of the Administration of the Corticosteroid

Kubo¹,

Ueki

Nohara

1976

The Journal of Dermatology

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The effects of corticosteroid administration on the immune deposits in the skin of reversed passive Arthus reaction (RPAR) using horseradish peroxidase as antigen were studied. Immune deposits were seen on vascular walls, on collagen fibers, at the dermo‐epidermal junction, at perifollicular regions, on mononuclear cells and in PMN‐leukocytes. By corticosteroid administration the amount of these immune deposits was most obviously reduced within the first 30 minutes after the induction of the RPAR. At 1, 4, 8, 24 and 48 hours after induction of the reaction there were no significant differences in the amount and the extent of the immune deposits on the vascular walls, on the collagen fibers and on the mononuclear cells, between the sections treated by corticosteroid and those of non‐treated specimens. The infiltration of PMN‐leukocytes and their uptake of immune complexes were maximum at 4 hours after the injection and the number of these infiltrated PMN‐leukocytes and the amount of immune complexes which were taken by them were slightly reduced by corticosteroid administration.

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Section: Discussionmentioning

confidence: 90%

Immune Deposits in the Skin of Reversed Passive Arthus Reaction. The Effects of the Administration of the Corticosteroid

Kubo¹,

Ueki

Nohara

1976

The Journal of Dermatology

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“…As regards drug-induced agranulocytosis, the majority of workers consider that the leucocyte agglutination is caused by a complex consisting of the protein-bound drug, which acts as a haptene, and its antibody (27,32). Theoretically corticosteroids will be effective because: 1) they inhibit the sensitization of the neutrophils with antibody (28,46), 2 ) the effect of the drug-protein complex is inhibited (theoretically), and 3) the production of neutrophils is increased (1 5, 22) (fig. 4).…”

Section: Agran Ulocytosismentioning

confidence: 99%