Untargeted metabolomics reveals altered branch chain amino acids, glucose and fat metabolism contributing to coronary artery disease among Indian diabetic patients

Adela, Ramu; Kasarla, Siva Swapna; Saquib, Najmuddin; Gupta, Sonu Kumar; Bajpai, Sneha; Kumar, Yashwant; Banerjee, Sanjay K.

doi:10.1039/d2mo00320a

Mol. Omics

2023

DOI: 10.1039/d2mo00320a

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Untargeted metabolomics reveals altered branch chain amino acids, glucose and fat metabolism contributing to coronary artery disease among Indian diabetic patients

Ramu Adela

Siva Swapna Kasarla

Najmuddin Saquib

et al.

Abstract: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic syndrome and is known to abet and accelerate the infestation of other systemic anomalies; cardiovascular dysfunction being the most common. Coronary...

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2024

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Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

Doğan

2024

Turkish Journal of Biochemistry

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Introduction Metabolomics is a rapidly growing field that aims to understand the complex metabolic pathways involved in health and disease. Liquid chromatography mass spectrometry (LC-MS) based untargeted metabolomics has emerged as a powerful tool for investigating the metabolic changes associated with various diseases, and for identifying potential biomarkers for early disease detection and treatment monitoring. This review provides a comprehensive overview of LC-MS based untargeted metabolomics and its clinical applications. Content The advantages and challenges of untargeted metabolomics are discussed, encompassing sample preparation, data processing, sample storage, acquisition mode selection, column strategy, and annotation. The latest advancements in LC-MS technology and data analysis techniques are reviewed, which have facilitated the more accurate and sensitive detection of metabolites in biological samples. The clinical applications of untargeted metabolomics are emphasized, including its utilization in disease diagnosis, treatment monitoring, and personalized medicine. Examples are provided of how biomarkers for various diseases, such as cancer, coronary heart disease, and infectious disease, have been identified through the application of untargeted metabolomics. Summary and outlook Overall, LC-MS based untargeted metabolomics is a powerful tool for investigating the complex metabolic changes associated with various diseases, and has the potential to transform clinical diagnosis, treatment, and personalized medicine.

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Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

Doğan

2024

Turkish Journal of Biochemistry

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Untargeted metabolomics reveals altered branch chain amino acids, glucose and fat metabolism contributing to coronary artery disease among Indian diabetic patients

Abstract: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic syndrome and is known to abet and accelerate the infestation of other systemic anomalies; cardiovascular dysfunction being the most common. Coronary...

Cited by 1 publication

References 51 publications

Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

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