Untargeted metabolomics revealed the regulatory effect of Maillard reaction products of ovalbumin with different degrees on the metabolism of colitis mice

Abstract

Maillard reaction (MR) is inevitable in food processing and daily cooking, but whether the MR degree would affect the biological activity of the protein in vivo remains unknown. In this...

Oral Synergism of Egg-White-Derived Peptides (EWDP) and Curcumin for Colitis Mitigation via Polysaccharide/Cyclodextrin Metal–Organic Framework-Based Assemblies

“…1) The adequate CMCS-EWDP coassembly significantly contributed to the superior aqueous solubility, physicochemical stability, and potential oral bioavailability of assemblies, which was essential to maximizing the outstanding physiological effects (e.g., anti-inflammatory and flora regulation) of Cur for UC mitigation. 2) Although EWDP and Cur were not significantly synergistic in direct anti-inflammatory (Figure ), the promising sacrificial behaviors and its metabolites could introduce indirect nutrition supplement (e.g., amino acids and peptide fragments) and mucosal repair, collaborating with Cur to restore intestinal microbiota homeostasis (e.g., enriching Lachnospiraceae and eliminating Bacteroides). , 3) Biopolymer-based templates (CMCS and MOF) of assemblies could not only extend the interaction duration time between Cur and gastrointestinal microenvironment via the potential swelling and mucoadhesive properties, but also function as an additional carbon source to selectively promote the growth of beneficial bacteria (e.g., Firmicutes and Clostridia). Therefore, the preferable coassembly between biopolymers and EWDP would be enlightening to improve the multiple applicability and oral efficacy of traditional MOF-based assemblies for healthcare applications (e.g., UC mitigation).…”

“…2 Besides, the long-term usage of mainstream clinical drugs (e.g., 5-aminosalicylic acid, 5-ASA) results in various serious side effects (e.g., nausea, cephalalgia, and accumulated biotoxicity), which further places a huge burden on the lifelong health care of citizens. 2,3 Therefore, developing novel and biofriendly strategies for treating UC is urgently needed in related biomedical areas.…”

“…Ulcerative colitis (UC), a refractory and recurrent inflammatory bowel disease (IBD), is generally characterized by a series of typical symptoms, such as weight loss, hematochezia, intestinal dysfunction, and severe dysbacteriosis . Due to the limited understanding of UC pathogenesis, there are few effective and acceptable treatments for alleviating colitis . Besides, the long-term usage of mainstream clinical drugs (e.g., 5-aminosalicylic acid, 5-ASA) results in various serious side effects (e.g., nausea, cephalalgia, and accumulated biotoxicity), which further places a huge burden on the lifelong health care of citizens. , Therefore, developing novel and biofriendly strategies for treating UC is urgently needed in related biomedical areas.…”