Untargeted metabolomics combined with 16S rRNA sequencing reveals the characteristics of intestinal metabolism and gut microbiota in hazelnut Cor a 14-allergic BALB/c mice
Chen Chen,
Kaiyu Mu,
Qiang Xie
et al.
Abstract:Cor a 14 is one of the most vital allergens in hazelnuts. However, the features of intestinal metabolites and microbiota associated with Cor a 14-induced allergy remain unclear. In this study, we established a hazelnut Cor a 14-allergic BALB/c mice model, which was distinguished by the dropped temperature and enhanced allergic inflammatory factor levels in serum. Faeces were collected to detect characteristics of the intestinal metabolites by untargeted metabolomics and the gut microbiota by 16S rRNA sequencin… Show more
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