Untargeted Metabolomics by Liquid Chromatography–Mass Spectrometry in Biomedical Research

Díaz, Caridad; González-Olmedo, Carmen

doi:10.1007/978-1-0716-2699-3_6

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The collision energy was applied in a range of 15 to 45 V. The mass spectrometer was operated in the information-dependent acquisition mode, in which the eight most intense candidates were fragmented in each analysis cycle [62].…”

Section: Analysis By Liquid Chromatography Coupled With High-resoluti...mentioning

confidence: 99%

Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM

Andújar-Vera,

Alés-Palmer,

Muñoz-de-Rueda

et al. 2023

IJMS

View full text Add to dashboard Cite

Hepatotoxicity, a common adverse drug effect, has been extensively studied in adult patients. However, it is equally important to investigate this condition in pediatric patients to develop personalized treatment strategies for children. This study aimed to identify plasma biomarkers that characterize hepatotoxicity in pediatric patients through an observational case–control study. Metabolomic analysis was conducted on 55 pediatric patients with xenobiotic liver toxicity and 88 healthy controls. The results revealed clear differences between the two groups. Several metabolites, including hydroxydecanoylcarnitine, octanoylcarnitine, lysophosphatidylcholine, glycocholic acid, and taurocholic acid, were identified as potential biomarkers (area under the curve: 0.817; 95% confidence interval: 0.696–0.913). Pathway analysis indicated involvement of primary bile acid biosynthesis and the metabolism of taurine and hypotaurine (p < 0.05). The findings from untargeted metabolomic analysis demonstrated an increase in bile acids in children with hepatotoxicity. The accumulation of cytotoxic bile acids should be further investigated to elucidate the role of these metabolites in drug-induced liver injury.

show abstract

Section: Analysis By Liquid Chromatography Coupled With High-resoluti...mentioning

confidence: 99%

Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM

Andújar-Vera,

Alés-Palmer,

Muñoz-de-Rueda

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism

Qin,

Yu,

Yang

et al. 2024

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Untargeted Metabolomics by Liquid Chromatography–Mass Spectrometry in Biomedical Research

Cited by 2 publications

References 30 publications

Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM

Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM

The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism

Contact Info

Product

Resources

About