Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne

Yu, Simin; Xiao, Zhilong; Yang, Xiaoliang OU; Wang, Xiuping; Deng, Zongquan; Li, Chunming

doi:10.1016/j.cca.2022.06.012

Cited by 12 publications

(11 citation statements)

References 38 publications

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“…The differential expression of 2-oxoadipic acid we observed has been reported in inflammatory diseases such as Behcet's disease and acne [22,23]. 2-oxoadipic acid is a common catabolic product of the essential amino acid lysine and tryptophan, of which the tryptophan pathway is considered to play a vital role in the regulation of inflammation and immunity [24,25].…”

Section: Plos Onesupporting

confidence: 54%

Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules

Wu,

Shen,

et al. 2023

PLoS ONE

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With the widespread application of low-dose computed tomography (LDCT) technology, pulmonary nodules have aroused more attention. Significant alteration in plasma metabolite levels, mainly amino acid and lipid, have been observed in patients of PNs. However, evidence on the association between central carbon metabolism and PNs are largely unknown. The aim of this study was to investigate the underlying association of PNs and plasma central carbon metabolites. We measured the levels of 16 plasma central carbon metabolites in 1954 participants who gained LDCT screening in MALSC cohort. The inverse probability weighting (IPW) technique was used to control for bias due to self-selection for LDCT in the assessed high-risk population. The least absolute shrinkage and selection operator (LASSO) penalized regression was used to deal with the problem of multicollinearity among metabolites and the combined association of central carbon metabolites with PNs was estimated by using quantile g-computation (QgC) models. A quartile increase in 3-hydroxybutyric acid, gluconic acid, succinic acid and hippuric acid was positively associated with the PNs risk, whereas a quartile increase in 2-oxadipic acid and fumaric acid was negatively associated with the risk of PNs in multiple-metabolite models. A positive but insignificant joint associations of the mixture of 16 metabolites with PNs was observed by using QgC models analyses. Further studies are warranted to clarify the association between circulating metabolites and PNs and the biological mechanisms.

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Section: Plos Onesupporting

confidence: 54%

Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules

Wu,

Shen,

et al. 2023

PLoS ONE

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“…Consistently, a previous study has identified the dysregulated sphingolipid metabolism in skin samples of the rat model of acne ( Chen et al, 2021 ). Meanwhile, our previous study also found that the sphingolipid signaling pathway was the most altered in plasma of moderate-to-severe acne patients ( Yu et al, 2022 ). Besides, SM can inhibit the differentiation of keratinocytes ( Pillai et al, 1999 ).…”

Section: Discussionmentioning

confidence: 86%

Nontargeted metabolomics to characterize the effects of isotretinoin on skin metabolism in rabbit with acne

et al. 2022

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Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. This study aimed to explore the pathogenesis of acne and the therapeutic mechanism of isotretinoin from the metabolic perspective in coal tar-induced acne in rabbits.Methods: Ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS) based metabolomics was used to identify skin metabolites in groups C (blank control), M (model group) and T (isotretinoin group). Multivariate statistical analysis was used to process the metabolomics data.Results: 98 differential metabolites in group C and group M were identified. The highest proportion of differential metabolites were organic acids and derivatives, lipid metabolites, organic heterocyclic compounds, and nucleoside metabolites. The most significant metabolic pathways included protein digestion and absorption, central carbon metabolism in cancer, ABC transporters, aminoacyl-tRNA biosynthesis, biosynthesis of amino acids, and sphingolipid signaling pathway. Isotretinoin treatment normalized eight of these metabolites.Conclusions: Our study will help to further elucidate the pathogenesis of acne, the mechanism of isotretinoin at the metabolite level, and identify new therapeutic targets for treating acne.

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“… 41 In addition, the sphingolipid signaling pathway was the most altered in the plasma of patients with moderate to severe acne. 42 It is well known that spicy foods can exacerbate acne.Hence, we speculate capsaicin may affect the progress of acne through the sphingolipid metabolism and sphingolipid signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study

Xiao,

Yu,

Zhang

et al. 2024

DDDT

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Background Capsaicin is the main compound found in chili pepper and has complex pharmacologic effects. This study aimed to elucidate the mechanism of the effect of capsaicin on physiological processes by analyzing changes in metabolites and metabolic pathways. Methods Female C57BL/6 mice were divided into two groups(n = 10/group) and fed with capsaicin-soybean oil solution(group T) or soybean oil(group C) for 6 weeks. Ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS) based metabolomics was undertaken to assess plasma and skin metabolic profile changes and identify differential metabolites through multivariate analysis. Results According to the OPLS-DA score plots, the plasma and skin metabolic profiles in the group T and group C were significantly separated. In plasma, 38 significant differential metabolites were identified. KEGG pathway enrichment analysis revealed that the most significant plasma metabolic pathways included pyruvate metabolism and ABC transporters. In skin, seven significant differential metabolites were found. Four metabolic pathways with p values < 0.05 were detected, including sphingolipid metabolism, sphingolipid signaling pathway, apoptosis, and necroptosis. Conclusion These findings will provide metabolomic insights to assess the physiological functions of capsaicin and contribute to a better understanding of the potential effects of a capsaicin-rich diet on health.

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Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne

Cited by 12 publications

References 38 publications

Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules

Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules

Nontargeted metabolomics to characterize the effects of isotretinoin on skin metabolism in rabbit with acne

UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study

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