Untargeted Metabolomic Profiling and Antioxidant Capacities of Different Solvent Crude Extracts of Ephedra foeminea

Al-Nemi, Ruba; Makki, Arwa A.; Sawalha, Khaled; Hajjar, Dina; Jaremko, Mariusz

doi:10.3390/metabo12050451

Cited by 17 publications

(15 citation statements)

References 71 publications

(77 reference statements)

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“…Few studies report the chemical constituents of C. grandis including the isolation of aloe-emodin from the leaf [ 22 ], 1,3,4-trihydroxy-6,7,8-trimethoxy-2-methyl anthraquinone-3-O-β-D- Glucopyranoside from the pod [ 23 ], and emodin-9-anthrone from the stem [ 24 ]. However, it is worth mentioning that this is the first detailed study on the phenolic profiles of these four species and this untargeted metabolomics approach would enable us to identify the composition of extracts to integrate biological knowledge, and, consequently, pinpoint pharmaceutical candidates [ 2 ].…”

Section: Resultsmentioning

confidence: 99%

“…Bioactive compounds derived from natural resources, especially from plants, provide huge potentials against a broad spectrum of pharmacological targets with beneficial effects on the human health care system [ 1 ]. Metabolomics has evolved in recent years as a comprehensive approach to examine a complex mixture of molecules that may be associated with observations obtained through biological activity tests without the need for isolation procedures; consequently, aiding the development of natural product-derived therapeutic agents [ 2 ]. A number of phytoconstituents with scientific evidences of their pharmacological potency have been discovered over the last few years.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

et al. 2022

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Several species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic content and antioxidant and enzyme inhibition activities of leaf methanolic extracts of C. fistula L., C. grandis L., S. alexandrina Mill., and S. italica Mill. The two Cassia spp. contained higher total polyphenolic content (42.23–49.75 mg GAE/g) than the two Senna spp., and C. fistula had significantly (p ˂ 0.05) the highest concentration. On the other hand, the Senna spp. showed higher total flavonoid content (41.47–59.24 mg rutin equivalent per g of extract) than that found in the two Cassia spp., and S. alexandrina significantly (p ˂ 0.05) accumulated the highest amount. HPLC–MS/MS analysis of 38 selected bioactive compounds showed that the majority of compounds were identified in the four species, but with sharp variations in their concentrations. C. fistula was dominated by epicatechin (8928.75 µg/g), C. grandis by kaempferol-3-glucoside (47,360.04 µg/g), while rutin was the major compound in S. italica (17,285.02 µg/g) and S. alexandrina (6381.85). The methanolic extracts of the two Cassia species exerted significantly (p ˂ 0.05) higher antiradical activity, metal reducing capacity, and total antioxidant activity than that recorded from the two Senna species’ methanolic extracts, and C. fistula displayed significantly (p ˂ 0.05) the highest values. C. grandis significantly (p ˂ 0.05) exhibited the highest metal chelating power. The results of the enzyme inhibition activity showed that the four species possessed anti-AChE activity, and the highest value, but not significantly (p ≥ 0.05) different from those obtained by the two Cassia spp., was exerted by S. alexandrina. The Cassia spp. exhibited significantly (p ˂ 0.05) higher anti-BChE and anti-Tyr properties than the Senna spp., and C. grandise revealed significantly (p ˂ 0.05) the highest values. C. grandise revealed significantly (p ˂ 0.05) the highest α- amylase inhibition, while the four species had more or less the same effect against the α-glucosidase enzyme. Multivariate analysis and in silico studies showed that many of the identified phenols may play key roles as antioxidant and enzyme inhibitory properties. Thus, these Cassia and Senna species could be a promising source of natural bioactive agents with beneficial effects for human health.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

et al. 2022

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“…Antioxidant properties of plant extracts are related to TPC that is dependent on solvents (aqueous or organic) used for extraction [5,14,[69][70][71][72]. In this research, phosphate buffer was used as a solvent in order to be further able to perform electrochemical experiments with the same extracts.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antioxidant and Prooxidant Activities of Red Raspberry (Rubus idaeus L.) Stem Extracts

et al. 2022

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Leaves and stems of red raspberry (Rubus idaeus) are used in Lithuanian folk medicine. Healing properties of raspberry are related to the content of bioactive compounds, mainly polyphenols. Extracts of raspberry leaves contained higher total phenolic content (TPC) (1290 mg/L, expressed in gallic acid equivalent) compared to that in extracts of stems or peeled bark (up to 420 mg/L and 598 mg/L, respectively). To find out whether the collection time of herbal material was critical for the properties of the extracts, the stems were collected at different times of the year. TPC in the extracts depended more on extraction conditions rather than on the sampling time. Antioxidant activity of raspberry stem and bark extracts tested by spectrophotometric (DPPH● scavenging) and electrochemical (cyclic and differential pulse voltammetry) assays correlated with TPC. DPPH radical scavenging activity values for stem, leaf, and bark extracts were as follows: ≤1.18 ± 0.07, 1.63 ± 0.10, and ≤1.90 ± 0.04 (mmol/L, TROLOX equivalent), respectively. Assessed electrochemically, hydrogen peroxide-scavenging activity of extracts was independent on TPC. The latter activity was related to the presence of some protein in the extract as revealed by gel electrophoresis. Prooxidant activity of raspberry stem extracts was dependent on solution pH and temperature.

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“…The coating technology is designed for the slow release of the nutritional content of fertilizers and synchronization of their release rate with the nutritional demand of the plants. The characteristics of the gradual release of nitrogen contents can be physically imparted to the urea by coating its granules with various materials which delay its dissolution rate (Naz and Sulaiman, 2016;Ullah et al, 2020;Badshah et al, 2021;Al-Nemi et al, 2022). Coated fertilizer (Figure 1) is believed to be the best solution under the current scenario to deliver nutrients to crops for enhancing their productivity, reducing nutrient losses, and minimizing the subsequent impact on the environment (Shivay et al, 2019;Shah et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Improving crop productivity and nitrogen use efficiency using sulfur and zinc-coated urea: A review

et al. 2022

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Nitrogen (N) is an important macro-nutrient required for crop production and is considered an important commodity for agricultural systems. Urea is a vital source of N that is used widely across the globe to meet crop N requirements. However, N applied in the form of urea is mostly lost in soil, posing serious economic and environmental issues. Therefore, different approaches such as the application of urea coated with different substances are used worldwide to reduce N losses. Urea coating is considered an imperative approach to enhance crop production and reduce the corresponding nitrogen losses along with its impact on the environment. In addition, given the serious food security challenges in meeting the current and future demands for food, the best agricultural management strategy to enhance food production have led to methods that involve coating urea with different nutrients such as sulfur (S) and zinc (Zn). Coated urea has a slow-release mechanism and remains in the soil for a longer period to meet the demand of crop plants and increases nitrogen use efficiency, growth, yield, and grain quality. These nutrient-coated urea reduce nitrogen losses (volatilization, leaching, and N2O) and save the environment from degradation. Sulfur and zinc-coated urea also reduce nutrient deficiencies and have synergetic effects with other macro and micronutrients in the crop. This study discusses the dynamics of sulfur and zinc-coated urea in soil, their impact on crop production, nitrogen use efficiency (NUE), the residual and toxic effects of coated urea, and the constraints of adopting coated fertilizers. Additionally, we also shed light on agronomic and molecular approaches to enhance NUE for better crop productivity to meet food security challenges.

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Untargeted Metabolomic Profiling and Antioxidant Capacities of Different Solvent Crude Extracts of Ephedra foeminea

Cited by 17 publications

References 71 publications

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

In Vitro Antioxidant and Prooxidant Activities of Red Raspberry (Rubus idaeus L.) Stem Extracts

Improving crop productivity and nitrogen use efficiency using sulfur and zinc-coated urea: A review

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