Untargeted metabolomic analysis reveals different metabolites associated with response to mepolizumab and omalizumab in asthma
Tanawin Nopsopon,
Yulu Chen,
Qingwen Chen
et al.
Abstract:BackgroundThere is limited evidence on biomarkers associated with response to the monoclonal antibodies currently approved for asthma treatment. We sought to identify circulatory metabolites associated with response to treatment with mepolizumab or omalizumab.MethodsWe conducted global metabolomic profiling of pre-treatment plasma samples from 100 patients with moderate-to-severe asthma who initiated mepolizumab (n=31) or omalizumab (n=69). The primary outcome was the change in exacerbations within 12 months o… Show more
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