Untargeted Metabolomic Analysis in Endolymphatic Sac Luminal Fluid from Patients with Meniere’s Disease

Huang, Li; Wang, Qin; Huang, Chao; Zhou, Zhou; Peng, Anquan; Zhang, Zhiwen

doi:10.1007/s10162-023-00887-1

Cited by 1 publication

(1 citation statement)

References 54 publications

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“…These findings suggest that the increase in 4-hydroxynonenal could be associated with oxidative damage and inflammatory lesions in MD. Additionally, the decrease in citrate and EDTA might be linked to disturbed endolymphatic Ca 2+ flux in MD patients [ 44 ].…”

Section: Investigating Inner Ear Diseases Through Proteomics and Meta...mentioning

confidence: 99%

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

Khorrami,

Pastras,

Haynes

et al. 2024

Proteomes

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Characterising inner ear disorders represents a significant challenge due to a lack of reliable experimental procedures and identified biomarkers. It is also difficult to access the complex microenvironments of the inner ear and investigate specific pathological indicators through conventional techniques. Omics technologies have the potential to play a vital role in revolutionising the diagnosis of ear disorders by providing a comprehensive understanding of biological systems at various molecular levels. These approaches reveal valuable information about biomolecular signatures within the cochlear tissue or fluids such as the perilymphatic and endolymphatic fluid. Proteomics identifies changes in protein abundance, while metabolomics explores metabolic products and pathways, aiding the characterisation and early diagnosis of diseases. Although there are different methods for identifying and quantifying biomolecules, mass spectrometry, as part of proteomics and metabolomics analysis, could be utilised as an effective instrument for understanding different inner ear disorders. This study aims to review the literature on the application of proteomic and metabolomic approaches by specifically focusing on Meniere’s disease, ototoxicity, noise-induced hearing loss, and vestibular schwannoma. Determining potential protein and metabolite biomarkers may be helpful for the diagnosis and treatment of inner ear problems.

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Section: Investigating Inner Ear Diseases Through Proteomics and Meta...mentioning

confidence: 99%

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

Khorrami,

Pastras,

Haynes

et al. 2024

Proteomes

View full text Add to dashboard Cite

show abstract

Untargeted Metabolomic Analysis in Endolymphatic Sac Luminal Fluid from Patients with Meniere’s Disease

Cited by 1 publication

References 54 publications

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

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