Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites

Kusari, Souvik; Pandey, Sarvesh; Spiteller, Michael

doi:10.1016/j.phytochem.2012.07.021

Cited by 190 publications

(124 citation statements)

References 63 publications

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“…1 ester (C-1'), confirming structure 5 of n-butyl-3,4-dihydroxybenzoate. Oddly enough, though all the data as can be seen from our discussion above led us towards the proposed structure, the integration of -CH 2 to the alkyl chain failed to be consistent with it.…”

Section: Resultsmentioning

confidence: 70%

“…1 These fungi present an enormous ability when it comes to the production of a wide range of new bioactive metabolites from a single strain through the systematic alteration of the cultivation parameters, known as the OSMAC (one strain many compounds) approach. The OSMAC mechanism came into being thanks to the observation that small changes in the cultivation conditions were capable of completely altering the metabolic profile of many microorganisms.…”

Section: Introductionmentioning

confidence: 99%

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One stain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungus from Alibertia macrophylla (Rubiaceae)

Gubiani¹,

Habeck²,

Chapla³

et al. 2016

Quim. Nova

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Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (RUBIACEAE). Seven phenolic derivatives including n-hexyl-3,4-dihydroxybenzoate (6) and n-octyl-3,4-dihydroxybenzoate (7) were produced using Camarops sp. via the one strain-many compounds (OSMAC) approach. Their structures were determined using 2D NMR and ESI-MS spectra and were compared with works reported in the literature. This paper deals with the first report of these compounds in Camarops sp.

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Section: Resultsmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

One stain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungus from Alibertia macrophylla (Rubiaceae)

Gubiani¹,

Habeck²,

Chapla³

et al. 2016

Quim. Nova

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“…The results of the present experiment also showed that AM fungi can play an important role in the accumulation of bioactive compounds in H. perforatum and that such effects could be related to the P uptake by the AMF partner. However, also other H. perforatum-fungi interactions could be involved in such effects, because both hyperforin and naphthodianthrones show antimicrobial and antifeedant activity (Kusari et al 2013) and an endophytic fungus of H. perforatum was able to produce hypericin in a growth medium without any compound from its host plant (Kusari et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate

et al. 2016

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St. John's Wort (Hypericum perforatum) is a perennial herb able to produce water-soluble active ingredients (a.i.), mostly in flowers, with a wide range of medicinal and biotechnological uses. However, information about the ability of arbuscular mycorrhizal fungi (AMF) to affect its biomass accumulation, flower production, and concentration of a.i. under contrasting nutrient availability is still scarce. In the present experiment, we evaluated the role of AMF on growth, flower production, and concentration of bioactive secondary metabolites (hypericin, pseudohypericin, and hyperforin) of H. perforatum under contrasting P availability. AMF stimulated the production of aboveground biomass under low P conditions and increased the production of root biomass. AMF almost halved the number of flowers per plant by means of a reduction of the number of flower-bearing stems per plant under high P availability and through a lower number of flowers per stem in the low-P treatment. Flower hyperforin concentration was 17.5% lower in mycorrhizal than in non-mycorrhizal plants. On the contrary, pseudohypericin and hypericin concentrations increased by 166.8 and 279.2%, respectively, with AMF under low P availability, whereas no effect of AMF was found under high P availability. These results have implications for modulating the secondary metabolite production of H. perforatum. However, further studies are needed to evaluate the competition for photosynthates between AMF and flowers at different nutrient availabilities for both plant and AM fungus.

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“…Moreover, endophytes comprise a promising rich source of potential bioactive medicinal constituents such as podophyllotoxin (Canel et al 2000), paclitaxel (Taxol) (Stierle et al 1993), hypericin (Kusari et al 2008) and camptothecin (Kusari et al 2009). Generally, medicinal plants used in traditional medicine are selected for surveying bioactive endophytic fungi due to documented beneficial applications (Kaul et al 2012; Kusari et al 2013) and thus, high likelihood of producing pharmaceutically important secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Pansanit

Pripdeevech

2018

Mycology

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Forty-four endophytes were isolated from Zingiber cassumunar and identified morphologically. The ethyl acetate extracts of all endophytes were obtained. The ethyl acetate extracts were subjected to study antibacterial and antioxidant activities. The ethyl acetate extract of the Arthrinium sp. MFLUCC16-1053 showed activity against both gram-positive and gram-negative bacteria. Specifically, the minimum inhibition concentration against Staphylococcus aureus and Escherichia coli was 31.25 and 7.81 µg/mL, respectively. In addition, the crude extract showed highest antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging at IC50 value of 28.47 µg/mL. Gas chromatography-mass spectrometry analysis revealed that the extract of the Arthrinium sp. MFLUCC16-1053 contains various antibacterial and antioxidant compounds which are β-cyclocitral, 3E-cembrene A, laurenan-2-one, sclareol, 2Z,6E-farnesol, cembrene, β-isocomene and γ-curcumene. The fungus Arthrinium sp. MFLUCC16-1053 was also identified by molecular and phylogenetic methods.

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Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites

Cited by 190 publications

References 63 publications

One stain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungus from Alibertia macrophylla (Rubiaceae)

One stain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungus from Alibertia macrophylla (Rubiaceae)

Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

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