Unsuspected Prostatic Adenocarcinoma in Patients Who Have Undergone Radical Cystoprostatectomy for Transitional Cell Carcinoma of The Bladder

Pritchett, Thomas R.; Moreno, José; Warner, Nicholas P.; Lieskovsky, Gary; Nichols, Peter W.; Cook, Bridgette A.; Skinner, Donald G.

doi:10.1016/s0022-5347(17)42864-3

Cited by 70 publications

(42 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Incidental prostate carcinoma rates detected in cases having undergone RCP due to bladder tumor vary between 4% and 60% (Table 2) (2,6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). One of the reasons for these various rates has been linked to the use of section intervals in different widths.…”

Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Balci¹,

Onuk²,

Hazar³

et al. 2016

JAREM

View full text Add to dashboard Cite

Objective: Prostate cancer (PC) is one of the major health problems among males. Pathology specimens of patients with incidental PC who underwent radical cystoprostatectomy (RCP) have been reported to be 17-70% in different series. In this study, we aimed to determine the frequencies and features of incidental PC in patients who underwent RCP.Methods: In our study, 142 patients who underwent RCP were retrospectively evaluated between 1999 and 2015. Women and patients diagnosed with PC before were excluded. Preoperative PSA levels were 2.05-9.31 ng/mL. Standard RSP and standard pelvic lymphadenectomy were performed.Results: Incidental PC was detected in 22 of 142 patients. The frequency of incidental PC was found to be 15.4% in RSP materials. In 10 of 22 patients with PC, high-grade prostatic intraepithelial neoplasia (PIN) areas were detected. Further, 14 of 120 patients without PC had highgrade PIN zones. In 140 patients, transitional cell carcinoma was detected, and the other 2 patients had signet ring cell carcinoma. In bladder specimens, 68 patients were in the T2 stage, while 58 patients and 16 patients were in the T3 and T4 stages, respectively. The Gleason score (GS) was 2+3=5 in 2 of the 22 incidental PC patients. Moreover, 6 patients had GS of 3+2=5 and 14 patients had GS of 3+3=6. Conclusion:Most incidentally detected PCs in RCP specimens are small, localized, and well-differentiated tumors. Extracapsular extension was not observed in any of them. Patients with invasive bladder tumors and PCs together have a lower T stage than those with only invasive bladder tumors. The risk of PC is higher in patients with invasive bladder cancer than in the healthy population. Preoperative prostate evaluation, prostate dissection, and resection should be performed with oncologic surgery. (JAREM 2016; 6: 15-8)

show abstract

Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Balci¹,

Onuk²,

Hazar³

et al. 2016

JAREM

View full text Add to dashboard Cite

show abstract

“…İnvaziv mesane kanseri nedeniyle RSP yapılmış hastaların incelendiği çalışma-larda rastlantısal prostat kanser sıklığı %17-70 arasında değişen oranlarda rapor edilmiştir (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) Yapılan çalışmalarda prostat kanseri ile mesanenin değişici epitel hücreli karsinomu arasındaki ilişki ortaya konmuş ve kontrol grubuna göre mesane kanseri olan hastalarda prostat kanseri sıklığının 9 kat arttığı gösterilmiştir (22). Chun (14) tarafından yapılan çalışmada, normal popülasyona göre riskin 19 kat arttığı rapor edilmiştir.…”

Section: Discussionunclassified

“…Yapılan bir çalışmada ameliyat öncesi parmak ile rektal muayenesi ve PSA seviyesi normal olan ve prostat koruyucu radikal sistektomi yapılan hastaların retrospektif analizinde, bu yöntemle ek onkolojik risk olmaksızın daha iyi üriner kontinans ve seksüel fonksiyon sonuçları sağladığı saptanmıştır (31). Ancak rastlantısal prostat kanser sıklığının yüksek olması, erkeklerde kanserden ölümlerde ikinci sırada yer alması ve en sık prostat apeksinin tutulması nedeniyle RSP esnasında prostat dokusunun tamamen çıkarılmasını öneren yazarların oranı daha fazladır (13,(16)(17)(18). Bununla birlikte her iki kanserin birlikte bulunmasının, her birinin tek başına bulunmasına göre prognozu değiştirmediği belirtilse de (32), erken tanının prognoza olan katkısı unutulmamalıdır (33)(34)(35).…”

Section: Discussionunclassified

Radikal sistoprostatektomi yapılan hastalarda prostat kanseri insidansı ve klinik önemi

Türk¹,

Karabıçak²,

Ün³

et al. 2015

Ege Tıp Dergisi

View full text Add to dashboard Cite

Amaç: Rastlantısal olarak radikal sistoprostatektomi (RSP) örneklerinde saptanan prostat adenokarsinomlarının çoğu lokalize ve iyi diferansiye klinik önemsiz kanserlerdir. Bu çalışmada RSP yapılan hastalarda rastlantısal saptanan prostat adenokanseri oranını saptamayı ve hastaların sağkalımlarına etkisini ortaya koymayı amaçladık. Gereç ve Yöntem:Eylül 2007 ile Mart 2014 tarihleri arasında mesane kanseri nedeniyle RSP yapılan hastalar retrospektif olarak incelendi. Hastaların cerrahi endikasyonu derin kas invazyonu olan üroteliyal karsinom veya transüretral rezeksiyon ile kontrol altına alınamayan yüksek dereceli değişici epitel hücreli karsinom olmasıydı. Tüm hastalara standart RSP ve iki taraflı genişletilmiş pelvik lenfadenektomi yapıldı. Sistoprostatektomi materyalinde tüm örnekler dikkate alınarak tümörün Gleason derecesi, prostatik intraepitelyal neoplazi (PIN) birlikteliği, ekstrakapsüler yayılım, seminal vezikül tutulumu ve lenf nodu metastazı değerlendirildi. Bulgular:Mesane üroteliyal kanseri nedeniyle RSP uygulanan 126 hastanın 26'sında (%20.6) rastlantısal prostat adenokanseri saptandı. Saptanan prostat kanserlerinin 16'sı pT2a (%61.5), 8'i T2c (%30.7) ve ikisi de T3b (%7.6) evresinde idi. Hastaların 18'inin Gleason skoru 6 ve altında, 6'sının 7 (4+3) ve iki hastanın da 9 (5+4) olarak tespit edildi. Sonuç: Mesane kanseri nedeniyle RSP yapılan hastalarda geride prostat dokusu bırakılmadan tüm prostat dokusu çıkarılmalıdır. Mesane ve prostat kanseri birlikteliğinin yüksek olduğu akılda tutulmalı, dikkatli ve detaylı patolojik incelemeye ihtiyaç vardır.

show abstract

“…Additionally, several studies have shown the high incidence of incidental prostate adenocarcinoma in specimens from cystoprostatectomies performed for treating bladder cancer (3,(6)(7)(8)(9). Some of them reported a predominance of tumors in the prostate apex (3,6).…”

Section: Introductionmentioning

confidence: 99%

Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

Romero¹,

Castro²,

Júnior³

et al. 2004

Int. braz j urol.

View full text Add to dashboard Cite

Objective: To assess the incidence of bladder carcinoma infiltrating the prostate and prostate adenocarcinoma in patients undergoing radical cystoprostatectomy due to bladder cancer, as well as to assess if the characteristics of the bladder neoplasia influence the prostatic involvement by this neoplasia.Materials and Methods: We retrospectively assessed 60 male patients, who underwent radical cystoprostatectomy between July 1997 and December 2003. Mean age was 66.7 years (40 and 93 years). The product of radical cystoprostatectomies was checked for involvement of urethra and prostate parenchyma by the primary neoplasia, and for the presence of associated prostate adenocarcinoma. Bladder neoplasia characteristics, such as localization, size, multifocality, association with in situ carcinoma and histological grade, were studied in order to assess the possibility of using such characteristics as predictive factors of prostate infiltration by bladder urothelial carcinoma.Results: We observed the presence of 20% of patients with bladder carcinoma infiltrating the prostatic urethra, 23.3% of patients with infiltration of the prostate parenchyma and 28.3% of patients with associate prostate adenocarcinoma, resulting in a total of 55% of patients with prostatic involvement (infiltrative bladder carcinoma and/or adenocarcinoma). We also observed a statistically significant correlation between tumor location in the trigone, the presence of in situ carcinoma and the histological grade of the bladder tumor with prostatic infiltration by the vesical neoplasia.Conclusion: The coexistence of prostatic neoplasia in patients operated for bladder neoplasia was frequent in our sample (55%). We observed that the prostatic infiltration by bladder tumors occurs more frequently with tumors located in the trigone, with associated in situ carcinoma and with high histological grade. There was no correlation between neoplastic infiltration of prostate and multifocality or size of the bladder tumor in the studied sample.

show abstract

Unsuspected Prostatic Adenocarcinoma in Patients Who Have Undergone Radical Cystoprostatectomy for Transitional Cell Carcinoma of The Bladder

Cited by 70 publications

References 7 publications

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Radikal sistoprostatektomi yapılan hastalarda prostat kanseri insidansı ve klinik önemi

Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

Contact Info

Product

Resources

About