Unsuspected multiples myeloma presenting as bilateral pleural effusion – a cytological diagnosis

Dhingra, Kajal Kiran; Singhal, Niti; Nigam, Sonu; Jain, Shilpa

doi:10.1186/1742-6413-4-17

Cited by 24 publications

(18 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6] Previous studies have highlighted that the IgA kappa subtype to be associated with majority of pleural effusions ranging up to 80%,[78] However, in the present study we demonstrated IgG kappa subtype on immunofixation.…”

Section: Discussioncontrasting

confidence: 81%

Cytology of plasma cell rich effusion in cases of plasma cell neoplasm

Gochhait

Dey

Verma

2016

J Cytol

View full text Add to dashboard Cite

Background:Multiple myeloma or plasmacytoma resulting in malignant effusion is rarely described in literature.Aims:In this paper, we have studied the seven rare cases of plasma cell infiltration in effusion fluid.Materials and Methods:We studied six cases of pleural fluid and one case of ascetic fluid. Detailed cytological features, clinical history, bone marrow examinations, serum electrophoresis, and immunofixation data were analyzed.Result:There were two cases of plasmacytoma, four cases of multiple myeloma, and one case of plasmablastic lymphoma. On cytology, all the cases showed excess plasma cells along with mesothelial cells and lymphocytes on effusion cytology smear.Conclusion:Plasma cell rich effusion in cases of plasma cell tumor is rare. However, on cytology these cases do not pose much problem if relevant history is known.

show abstract

Section: Discussioncontrasting

confidence: 81%

Cytology of plasma cell rich effusion in cases of plasma cell neoplasm

Gochhait

Dey

Verma

2016

J Cytol

View full text Add to dashboard Cite

show abstract

“…Approximately 80 cases of MPE have been reported in the English literature, and we analyzed the clinical characteristics of 57 cases [3,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] based on information and articles we found in MEDLINE (table 1). The mean age of MPE patients was 59 years, with similar gender distribution, and the left pleural cavity was more commonly involved.…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma with Myelomatous Pleural Effusion: A Case Report and Review of the Literature

Kim¹,

Kim²,

Min³

et al. 2008

Acta Haematol

View full text Add to dashboard Cite

Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. Pleural effusion may develop in the setting of MM due to various reasons, but myelomatous pleural effusion (MPE) is rare. We report a case of MPE in a patient with advanced MM. A 76-year-old woman with MM was admitted to hospital because of dyspnea. Chest X-ray showed right-sided pleural effusion. Protein electrophoresis of the pleural fluid showed monoclonal protein, and cytology demonstrated monoclonal plasma cells. Hospice care was implemented, and the patient died one month later. We present an analysis of the clinical characteristics of 57 MPE cases reported in the English literature. Our review revealed that MPE patients had poor overall survival irrespective of whether MPE develops in the course of their disease or presents as the initial manifestation of MM. Based on this analysis, MPE is a poor prognostic factor, and aggressive treatment should be considered, especially for patients with early-onset MPE.

show abstract

“…The presence of an IgA paraprotein is most commonly associated with myelomatous pleural effusions, (in upto 80% of cases in some studies) [3,5]. The development of myelomatous pleural effusions is frequently a late complication of the disease and is associated with poor prognosis, with previous studies reporting median survival of less than 4 months [6,7]. It is interesting to note that in our case, histological analysis demonstrated presence of plasmoid cells.…”

Section: Discussionmentioning

confidence: 56%