Unsupervised Phenotype-Based Clustering of Clinicopathologic Features in Cutaneous Melanoma

Abstract

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A review of nevus‐associated melanoma: What is the evidence?

“…Interestingly, through machine learning, five clusters of melanomas were identified which occupied two distinct clinicopathologic subspaces: a lower‐grade partition associated with acquired melanocytic nevi (NAM) and a higher‐grade partition lacking precursor lesions ( de novo melanoma). The authors' model confirmed differences between NAM and de novo melanoma previously reported in observational studies, showing that de novo melanoma was more mitogenic, ulcerative and thicker than NAM 39 …”

“…The authors' model confirmed differences between NAM and de novo melanoma previously reported in observational studies, showing that de novo melanoma was more mitogenic, ulcerative and thicker than NAM. 39…”