Unsuccessful Suicide Attempt With Tiapride

Abstract

To the best of our knowledge, no case has been published in the literature that reports an overdose of tiapride, either alone or in combination with other drugs. We report a self-poisoning case in an 18-year-old girl, with approximately 10 times the usual daily dose (ie, 2.5 g). Although the blood concentration was 20/30-fold higher than usually observed after therapeutic drug intakes (17,300 mcg/L), the patient remained almost asymptomatic.

Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review

“…Tiapride is an antagonist of dopaminergic D 2 and D 3 receptors that is used to treat numerous movement disorders,e.g., tardive dyskinesia (Dose & Lange, ), agitation in the elderly (Robert & Allain, ) and senile dementia (Yuan, Li, Huang, & Lei, ). It is the first‐line therapy of Tourette syndrome in Europe (Roessner et al, ) and is relatively non‐toxic, causing virtually no acute adverse effects even at blood concentrations 20–30 times higher than those recommended for therapeutic use (Couderc, Mourou, Monchaud, & Saint‐Marcoux, ). In addition to its antidopaminergic properties, tiapride also reversibly inhibits AChE activity (Fontaine & Reuse, ) and protects AChE in vitro from inhibition by paraoxon (Petroianu, Hasan, et al, ) and dichlorvos (Petroianu, Schmitt, Arafat, & Hasan, ).…”