Unstable abnormal hemoglobins found in Russia in the past 10 years

Abstract

From 2010 to 2020, we investigated 197 children with hemolytic anemia of unknown etiology at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. Fifty-four of them were found to have hemoglobinopathy caused by unstable abnormal hemoglobins: Hb Monroe/Kairouan, Hb Tacoma, Hb Köln/SanFrancisco, Hb Cheverly, Hb City of Hope, Hb Southampton/Casper, Hb M-Hyde Park/Akita/Milwaukee-2, Hb Buenos Aires/Bryn Mawr, Hb Louisville/Bucureşti, Hb Genova/Hyogo, Hb Roseau-Pointe a Pitre, Hb Bristol/Alesha, Hb Henri Mondor, Hb Knossos, Hb Leiden, Hb Little Venice, Hb Olmsted, Hb Sabine, Hb Showa-Yakushiji, Hb Terre Haute, Hb Tübingen, Hb Quin-Hai. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. The patients' parents signed the informed consent for molecular genetic testing and gave their consent to the use of their children's data, including photographs, for research purposes and in publications.