1980
DOI: 10.1016/0165-1218(80)90095-6
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Unscheduled DNA synthesis and chromosome aberrations induced by inorganic and organic selenium compounds in the presence of glutathione

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Cited by 61 publications
(12 citation statements)
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“…Even when the synthase is inhibited, sleep may be maintained by the PGD2 already present in the brain until it reaches a level too low to be effective. Some in vitro studies reported previously provide data suggesting that selenocompounds react with thiols such as glutathione and DTT to form products that in turn play a vital role in many metabolic reactions (17)(18)(19)(20). Islam et al (11) also showed in their in vitro study that small amounts of DTT were required for the inhibition of PGD synthase by selenocompounds.…”
Section: Discussionmentioning
confidence: 80%
“…Even when the synthase is inhibited, sleep may be maintained by the PGD2 already present in the brain until it reaches a level too low to be effective. Some in vitro studies reported previously provide data suggesting that selenocompounds react with thiols such as glutathione and DTT to form products that in turn play a vital role in many metabolic reactions (17)(18)(19)(20). Islam et al (11) also showed in their in vitro study that small amounts of DTT were required for the inhibition of PGD synthase by selenocompounds.…”
Section: Discussionmentioning
confidence: 80%
“…Ganther et al reported a sequence of reactions between selenite and sulfhydryl compounds such as glutathione (GSH) to form hydrogen selenide (Ganther 1966(Ganther , 1968(Ganther , 1971Ganther and Corcoran 1969;Hsieh and Ganther 1975). Selenite cytotoxicity was enhanced by the addition of GSH or tissue extract containing GSH to the culture medium of cultured mammalian cells (Ray and Correspondence to: N. Imura Altenburg 1978; Whiting et al 1980;Batist et al 1986;Snyder 1987). Further, GSH-depleted sheep erythrocytes were not lysed by selenite treatment (Young et al 1981).…”
Section: Introductionmentioning
confidence: 93%
“…However, according to the available literature, the toxicity of selenium toward animal cells and yeast cells shares many features. For instance, with animal cells: (i) thiols have been observed to enhance the accumulation of selenium (66 -68) and the toxicity of selenite (21,66,69); (ii) hydrogen selenide toxicity has been recognized very early (70); and (iii) redox phenomena (24,25,71) as well as mitochondria (72) are involved in the toxicity mechanisms of selenocompounds. Interestingly, in bacteria also, redox phenomena are involved in the toxicity of selenite (73).…”
Section: Discussionmentioning
confidence: 99%