Unsaturation pattern of phosphatidylglycerols modulating the interaction of lysicamine with cells membrane models at the air-water interface

Machado, André Campos; Silva, Tamiris Reissa Cipriano da; Raminelli, Cristiano; Caseli, Luciano

doi:10.1016/j.colsurfb.2022.113045

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…Although there are fewer studies specifically focusing on small hydrophobic drug interactions with DOPE monolayers compared to DPPE, certain trends have emerged. Some drugs may exhibit reduced interaction with DOPE compared to DPPE due to electrostatic repulsion between the positively charged drug and the DOPE headgroup . Generally, neutral hydrophobic drugs are expected to partition into DOPE monolayers compared to charged drugs more readily.…”

Section: Resultsmentioning

confidence: 99%

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Surface Chemistry of Cytosporone-B Incorporated in Models for Microbial Biomembranes as Langmuir Monolayers

Jaroque,

dos Santos,

Sartorelli

et al. 2024

Langmuir

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Cytosporone-B, a polyketide renowned for its antimicrobial properties, was integrated into Langmuir monolayers composed of dipalmitoylphosphoethanolamine (DPPE) and dioleoylphosphoethanolamine (DOPE) lipids, effectively emulating microbial cytoplasmic membranes. This compound exhibited an expansive influence on DPPE monolayers while inducing condensation in DOPE monolayers. This led to a notable reduction in the compressibility modulus for both lipids, with a more pronounced effect observed for DPPE. The heightened destabilization observed in DOPE monolayers subjected to biologically relevant pressures was particularly noteworthy, as evidenced by surface pressure−time curves at constant area. In-depth analysis using infrared spectroscopy at the air−water interface unveiled alterations in the alkyl chains of the lipids induced by cytosporone-B. This was further corroborated by surface potential measurements, indicating a heightened tilt in the acyl chains upon drug incorporation. Notably, these observed effects did not indicate an aggregating process induced by the drug. Overall, the distinctive impact of cytosporone-B on each lipid underscores the importance of understanding the nuanced effects of microbial drugs on membranes, whether in condensed or fluid states.

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Section: Resultsmentioning

confidence: 99%

“…Some drugs may exhibit reduced interaction with DOPE compared to DPPE due to electrostatic repulsion between the positively charged drug and the DOPE headgroup. 47 Generally, neutral hydrophobic drugs are expected to partition into DOPE monolayers compared to charged drugs more readily.…”

Section: Resultsmentioning

confidence: 99%