Unsaturated alginate oligosaccharides (UAOS) protects against dextran sulfate sodium-induced colitis associated with regulation of gut microbiota

He, Ningning; Yang, Yue; Wang, Haoyu; Liu, Nian; Yang, Zizhen; Li, Shangyong

doi:10.1016/j.jff.2021.104536

Cited by 26 publications

(17 citation statements)

References 46 publications

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“…Indeed, AOS increase p-AMPK levels and decrease the ΝF-κB p65 abundance, clearly improving TJ functionality [ 225 ]. In addition, these findings agree with studies on dextran sulfate sodium (DSS)-challenged [ 239 ] and HFD-fed [ 240 ] mice, as well as in mucositis-challenged mice treated with AOS originated-fecal microbiota transplants [ 241 ]. Not surprisingly, unsaturated AOS (UAOS) and AOS supplementation alleviates inflammatory responses and restores dysbiotic populations, thus rescuing TJ protein abundance and conferring overall protection to the intestinal barrier of the mice.…”

Section: Non-digestible Oligosaccharides: Their Role In Tj Modulationsupporting

confidence: 88%

Direct Action of Non-Digestible Oligosaccharides against a Leaky Gut

et al. 2022

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The epithelial monolayer is the primary determinant of mucosal barrier function, and tight junction (TJ) complexes seal the paracellular space between the adjacent epithelial cells and represent the main “gate-keepers” of the paracellular route. Impaired TJ functionality results in increased permeation of the “pro-inflammatory” luminal contents to the circulation that induces local and systemic inflammatory and immune responses, ultimately triggering and/or perpetuating (chronic) systemic inflammatory disorders. Increased gut leakiness is associated with intestinal and systemic disease states such as inflammatory bowel disease and neurodegenerative diseases such as Parkinson’s disease. Modulation of TJ dynamics is an appealing strategy aiming at inflammatory conditions associated with compromised intestinal epithelial function. Recently there has been a growing interest in nutraceuticals, particularly in non-digestible oligosaccharides (NDOs). NDOs confer innumerable health benefits via microbiome-shaping and gut microbiota-related immune responses, including enhancement of epithelial barrier integrity. Emerging evidence supports that NDOs also exert health-beneficial effects on microbiota independently via direct interactions with intestinal epithelial and immune cells. Among these valuable features, NDOs promote barrier function by directly regulating TJs via AMPK-, PKC-, MAPK-, and TLR-associated pathways. This review provides a comprehensive overview of the epithelial barrier-protective effects of different NDOs with a special focus on their microbiota-independent modulation of TJs.

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Section: Non-digestible Oligosaccharides: Their Role In Tj Modulationsupporting

confidence: 88%

Direct Action of Non-Digestible Oligosaccharides against a Leaky Gut

et al. 2022

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“…Moreover, the TLR-4-mediated cascade reaction has been restricted and the expression of the relative cytokines remarkably reduced. 98…”

Section: The Application Of Different Kinds Of Functional Oligosaccha...mentioning

confidence: 99%

“…Moreover, the TLR-4mediated cascade reaction has been restricted and the expression of the relative cytokines remarkably reduced. 98 AOS have been demonstrated to have a wide range of antiinflammatory activities and intestinal epithelial barrier protective functions, which are closely associated with alterations in the gut microbiota. Taken together, AOS have great potential as a prebiotic.…”

Section: Food and Function Reviewmentioning

confidence: 99%

The role of functional oligosaccharides as prebiotics in ulcerative colitis

et al. 2022

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“…In the study of Wan et al [ 18 ], AOS were shown to ameliorate ETEC-induced jejunal injury in weaned pigs by decreasing jejunal TNF-α and IFN-γ concentrations and increasing jejunal occludin protein abundance. In the study of He et al [ 38 ], UAOS were found to attenuate DSS-induced colitis in mice by reducing the expression of inflammatory factors (COX-2 and TNF-α) and upregulating the expression of tight-junction proteins (ZO-1 and occludin). In the present study, AOS intervention was shown to significantly prevent colon shortening, body weight loss, rectal bleeding, and DAI scores, resulting in reduced ileal and colonic damages, low levels of IL-1β, IL-6, TNF-α and IFN-γ, and high levels of IL-10 in AOS-treated mice, suggesting that AOS could inhibit DSS-induced ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Alginate Oligosaccharides Ameliorate DSS-Induced Colitis through Modulation of AMPK/NF-κB Pathway and Intestinal Microbiota

Zhang

Guo

et al. 2022

Nutrients

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Alginate oligosaccharides (AOS) are shown to have various biological activities of great value to medicine, food, and agriculture. However, little information is available about their beneficial effects and mechanisms on ulcerative colitis. In this study, AOS with a polymerization degree between 2 and 4 were found to possess anti-inflammatory effects in vitro and in vivo. AOS could decrease the levels of nitric oxide (NO), IL-1β, IL-6, and TNFα, and upregulate the levels of IL-10 in both RAW 264.7 and bone-marrow-derived macrophage (BMDM) cells under lipopolysaccharide (LPS) stimulation. Additionally, oral AOS administration could significantly prevent bodyweight loss, colonic shortening, and rectal bleeding in dextran sodium sulfate (DSS)-induced colitis mice. AOS pretreatment could also reduce disease activity index scores and histopathologic scores and downregulate proinflammatory cytokine levels. Importantly, AOS administration could reverse DSS-induced AMPK deactivation and NF-κB activation in colonic tissues, as evidenced by enhanced AMPK phosphorylation and p65 phosphorylation inhibition. AOS could also upregulate AMPK phosphorylation and inhibit NF-κB activation in vitro. Moreover, 16S rRNA gene sequencing of gut microbiota indicated that supplemental doses of AOS could affect overall gut microbiota structure to a varying extent and specifically change the abundance of some bacteria. Medium-dose AOS could be superior to low- or high-dose AOS in maintaining remission in DSS-induced colitis mice. In conclusion, AOS can play a protective role in colitis through modulation of gut microbiota and the AMPK/NF-kB pathway.

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Unsaturated alginate oligosaccharides (UAOS) protects against dextran sulfate sodium-induced colitis associated with regulation of gut microbiota

Cited by 26 publications

References 46 publications

Direct Action of Non-Digestible Oligosaccharides against a Leaky Gut

Direct Action of Non-Digestible Oligosaccharides against a Leaky Gut

The role of functional oligosaccharides as prebiotics in ulcerative colitis

Alginate Oligosaccharides Ameliorate DSS-Induced Colitis through Modulation of AMPK/NF-κB Pathway and Intestinal Microbiota

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