Unresponsiveness of C-reactive protein in the non-infectious inflammation of systemic lupus erythematosus is associated with interleukin 6

Suh, Chang‐Hee; Chun, Hye-Young; Ye, Young-Min; Park, Hae‐Sim

doi:10.1016/j.clim.2005.11.006

Cited by 36 publications

(30 citation statements)

References 30 publications

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“…However, most SLE patients do not have elevated levels, but elevated serum IL-6 levels with increased CRP have been observed in SLE patients with infection or serositis. We confirmed that cytokine IL-6 and CRP responses were related in SLE; the response in infection was higher than that of serositis and tissue injury, and nearly no response in other noninfectious lupus disease activity [31].…”

Section: Cytokines and Cytokine Receptorssupporting

confidence: 71%

Biomarkers for systemic lupus erythematosus: an update

Kim

Jung²,

Suh³

2015

International Journal of Clinical Rheumatology

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Section: Cytokines and Cytokine Receptorssupporting

confidence: 71%

Biomarkers for systemic lupus erythematosus: an update

Kim

Jung²,

Suh³

2015

International Journal of Clinical Rheumatology

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“…Serum concentrations of C-reactive protein (CRP) in humans are indicative of inflammation and pathological progression of an infection. However, we reported there is little or no increase in CRP levels in non-infectious inflammation of SLE (Suh et al 2001(Suh et al , 2006. Additionally, we found that a -390 C>A or T polymorphism within the CRP promoter region might be involved in the regulation of CRP expression and the susceptibility of SLE in Koreans (Kim et al 2009a).…”

Section: Introductionmentioning

confidence: 71%

<i>FcγRIIB </i>Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans

Jeon

Kim

et al. 2015

Tohoku J. Exp. Med.

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Systemic lupus erythematosus (SLE) is chronic autoimmune disease with various autoantibodies, which are involved in tissue damage. Fc gamma receptors (Fcγ Rs) bind the constant region of the immunoglobulin G and transmit stimulatory or inhibitory signal to immune cells. The FcγR genes map to 1q23, a susceptible locus for SLE. We have screened single nucleotide polymorphisms (SNPs) in one of FcγR gene, FcγRIIB, which is the only inhibitory receptor, after considering gene map and reported SNPs. There were 3 SNPs in FcγRIIB: 10849 T>C (rs1050501) in exon 5 and 10950 T>G (rs6666965) and 11045 G>T (rs12117530) in intron 5 in Koreans. The frequency of the minor allele (T) of rs12117530 was significantly higher in SLE patients (50 patients, 20.4%) than healthy controls (17 patients, 12%, p = 0.041). Leukopenia occurred more frequently in SLE patients carrying the minor allele (T) of rs12117530 (p = 0.032). Among 5 haplotypes, the frequency of decreased complement was significantly lower in SLE patients with haplotype 1 [TTG] (p = 0.045). Nephritis, lymphopenia and anti-dsDNA antibody were significantly less frequent in SLE patients with haplotype 2 [TGG] (p = 0.046, p = 0.018, p = 0.002, respectively). The frequency of thrombocytopenia and anti-dsDNA antibody was significantly higher in SLE patients with haplotype 3 [CTG] (p < 0.001, p = 0.04, respectively). These data reveal that genetic polymorphisms within Fcγ RIIB are associated with disease susceptibility and phenotypes of SLE in Koreans. Furthermore, FcγRIIB rs12117530 polymorphism (T allele) may be an important risk factor in SLE.

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“…Elevated levels of CRP are found in the sera of patients with SLE who present concurrent infections 5,6 . However, moderately increased CRP levels are also found in cases of SLE-associated serositis and arthritis 3,6 . The range of CRP levels in SLE patients with infection sometimes overlaps considerably with those of SLE patients with flares 7 .…”

mentioning

confidence: 99%

“…It is known that C-reactive protein (CRP) levels are not elevated during SLE flares, making the factor unsuitable for monitoring disease activity 3,4 . Elevated levels of CRP are found in the sera of patients with SLE who present concurrent infections 5,6 .…”

mentioning

confidence: 99%