Unresectable hepatic tumors in childhood and the role of liver transplantation

Achilleos, Orthodoxos; Buist, L.; Kelly, Déirdre; Raafat, F.; McMaster, P; Mayer, A. D.; Buckels, J. A. C.

doi:10.1016/s0022-3468(96)90179-7

Cited by 75 publications

(36 citation statements)

References 41 publications

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“…Five of fourteen (36%) children transplanted were alive and well 1-5 years after transplant [29,36,42,49]. There are some reports of long-term survival after OLT for epithelial hemangioendothelioma, with Penn [30] reporting a 5 year survival of 43%, but there were no survivors among 14 patients grafted for hemangiosarcoma.…”

Section: Pediatric Olt For Malignant Tumorsmentioning

confidence: 99%

Liver transplantation for malignant liver tumors in children

Dower

Smith

2000

Med. Pediatr. Oncol.

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Section: Pediatric Olt For Malignant Tumorsmentioning

confidence: 99%

Liver transplantation for malignant liver tumors in children

Dower

Smith

2000

Med. Pediatr. Oncol.

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“…In a series of adults treated with transplantation, 5-year survival was 60.2% [9]. A similar series in children has not been published but individual cases have been reported; tumor recurrence and death after transplantation was reported in one such case [10].…”

Section: Treatmentmentioning

confidence: 95%

“…Total hepatectomy and liver transplantation is an alternative for these children. Survival in a few small series ranges from 50% to 80% [10,[35][36][37]. Children with multifocal tumors and extrahepatic disease at the time of transplantation had a worse prognosis.…”

Section: Treatmentmentioning

confidence: 99%

Pediatric liver tumors

Reynolds

1999

Semin. Surg. Oncol.

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An infant or child who presents with a large intrahepatic mass will most likely have a malignant tumor. In children, benign tumors constitute only 30% of liver tumors and most are vascular in origin. Treatment of benign vascular tumors is conservative and seldom surgical. Hepatoblastoma is the most common malignant tumor followed by hepatocellular carcinoma. Treatment of malignant tumors is based on a combination of surgery and chemotherapy. Children with hepatic malignancies that can be resected have an excellent prognosis. Other rare benign and malignant tumors of the liver do occur and surgery plays a critical role in management. Semin. Surg. Oncol. 16:159–172, 1999. © 1999 Wiley‐Liss, Inc.

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“…42 Recent results of liver transplantation for hepatocellular carcinoma in children are shown in Table 2. 24,32,36,[43][44][45][46][47][48] One of the largest series 24 was an update of a previous report from Pittsburgh. 49 In this report, 14 of 19 children with hepatocellular carcinoma had underlying chronic liver disease (tyrosinaemia, progressive familial intrahepatic cholestasis, hepatitis B, etc.).…”

Section: Survival and Prognosismentioning

confidence: 99%

“…5). [65][66][67][68] Not all cases have survived either because of cerebral bleeding (possibly related to an associated cerebrovascular malformation), 62,66 metastases from a type 2 HE, 45 or transplant-related complications.…”

Section: Hepatic Haemangioendotheliomamentioning

confidence: 99%

The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

Stringer

2007

annals

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In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver diseasethey typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

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Unresectable hepatic tumors in childhood and the role of liver transplantation

Cited by 75 publications

References 41 publications

Liver transplantation for malignant liver tumors in children

Liver transplantation for malignant liver tumors in children

Pediatric liver tumors

The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

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