Unrecognized Renal Cell Carcinoma

Hellsten, Sverker; Berge, Thorbjörn; Wehlin, L

doi:10.3109/00365598109179616

Cited by 38 publications

(6 citation statements)

References 24 publications

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“…In the Hradec Králové area, the incidence was largely constant (1.55%). In the study performed by Hellsten et al [10, 11] in Malmö, 350 RCCs were found among 16,294 autopsies (2.15%) from 1958 to 1969. In 115 cases (32.9%) the RCCs were clinically recognized and 235 (67.1%) were clinically unrecognized.…”

Section: Discussionmentioning

confidence: 99%

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Increase of Renal Cell Carcinoma Incidence in Central Europe

Wunderlich¹,

Schumann²,

Jantitzky³

et al. 1998

European Urology

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Section: Discussionmentioning

confidence: 99%

“…It is uncertain up to now, whether this increase of incidence is reality or not. In a series of 16,294 autopsies in Malmö, 350 RCCs were detected by Hellsten et al [10, 11, 12] during the years 1958–1969. Of these tumors, 235 (67.14%) were clinically unrecognized.…”

Section: Introductionmentioning

confidence: 99%

Increase of Renal Cell Carcinoma Incidence in Central Europe

Wunderlich¹,

Schumann²,

Jantitzky³

et al. 1998

European Urology

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“…Hölzel u. Altwein beschrieben für Deutschland eine Zunahme der Nierenzellkarzinom-Inzidenz in den letzten Jahren um 15 bis 20 % [10] [8,9]. Somit muû von einer hohen Rate sogenannter inzidenteller Nierenkarzinome ausgegangen werden.…”

Section: Nierenzellkarzinom · Inzidenz · Ultraschallunclassified

Is the increased incidence of renal cell carcinoma in Central-Europe really or not?

et al. 1999

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In the last years the incidence of renal cell carcinoma diagnosis increased about 15-20%. The main aim of this study was to analyse the reason of the increase of incidence. In the present autopsy series comprising 23,801 autopsies the percentage of patients who died of renal cell carcinoma is 1.77% in Jena and 1.55% in Königgrätz (200,000 inhabitants each). Over this time the incidence of renal cell carcinoma in autopsies has increased. In spite of the increased amount of incidentally found renal cell carcinomas since beginning widespread use of ultrasonography the percentage of clinically recognized renal cell carcinomas on the total of all found renal cell carcinomas in autopsies is nearly constant about the 12-year period in Jena and 10-year period in Königgrätz. Thus, the increased number of radical nephrectomies is not only caused by widespread use of ultrasonography. The increasing trend of the incidence of renal cell carcinoma seems to be real.

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“…The annual rate of the incidentally found carcinomas has increased up to 70% [10]. However, in a series of 16,294 autopsies in Malmö out of 350 RCCs (67.14%) revealed by Hellsten et al [12][13][14] during the years of 1958-1969 235 RCC were clinically unrecognized. Among the 235 clinically unrecognized tumors 56 cases (24%) with metastatic spread were revealed.…”

Section: Introductionmentioning

confidence: 99%

Renal Cell Carcinoma in Renal Graft Recipients and Donors: Incidence and Consequence

Wunderlich

Wilhelm²,

Reichelt³

et al. 2001

Urol Int

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Introduction and Objectives: Numerous studies have reported an increasing incidence of small renal cell carcinoma (RCC). De novo RCC in a renal allograft is a rare event and has special implications in renal transplant recipients. The objective of this study was to retrospectively evaluate the incidence of RCC in renal graft recipients and donors and to determine a procedure in cases with newly detected small renal tumors at the time of kidney preparation before transplantation. Material andMethods: We mailed a questionnaire to 38 German transplant clinics and received answers from 27 centers. A total of 10,997 renal graft recipients were included in the period of 1990–1998. Results: In 30 kidneys (0.273%) RCC was detected at the time of preparation before transplantation. There were 23 male and 3 female donors. No bilateral RCC was described. The mean age of the donors with RCC was 50.9 years (range 37–72 years). The tumors had a mean size of 2.2 cm (range 0.4–6 cm). 67% of the patients had a renal tumor smaller than 20 mm. In 26/27 centers the decision to transplant relies on the result of the immediate section for microscopic examination. 16 patients (0.145%) developed RCC 3–12 years after renal transplantation (mean 7.4 years). The mean tumor size was 2.5 cm (range 2–2.8 cm). In 50% a grade 1 and in the other 50% a grade 2 carcinoma was found. Conclusions: Because of the RCC incidence in donor candidates we recommend an ultrasound screening of the native kidneys before renal explantation and an immediate preparation of the kidney surface especially in donors older than 45 years. In cases with small renal lesions we recommend an immediate section for microscopic examination before transplantation to prevent tumor implantation into an otherwise healthy patient. The frequency of RCCs after renal transplantation necessitates careful clinical and instrumental examinations in organ-transplanted recipients both before and at regular intervals after transplantation, including the patient’s kidneys.

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Unrecognized Renal Cell Carcinoma

Cited by 38 publications

References 24 publications

Increase of Renal Cell Carcinoma Incidence in Central Europe

Increase of Renal Cell Carcinoma Incidence in Central Europe

Is the increased incidence of renal cell carcinoma in Central-Europe really or not?

Renal Cell Carcinoma in Renal Graft Recipients and Donors: Incidence and Consequence

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