2023
DOI: 10.1016/j.redox.2023.102819
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Unravelling the role of NFE2L1 in stress responses and related diseases

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Cited by 13 publications
(5 citation statements)
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“…Previous studies have indicated that AT accumulation in the mesentery is accompanied by inflammation. Although there are a limited number of studies that explore NFE2L1 expression as a direct cause of Crohn's disease, its typical genetic association and functional significance in other IBDs suggest that it may play an important role [56,57]. The expression levels of lncRNA G8110 and NFE2L1 were decreased in the WG group, and lncRNA G8110 showed beneficial effects by promoting lipid metabolism and inhibiting adipose inflammation (Figure 4).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have indicated that AT accumulation in the mesentery is accompanied by inflammation. Although there are a limited number of studies that explore NFE2L1 expression as a direct cause of Crohn's disease, its typical genetic association and functional significance in other IBDs suggest that it may play an important role [56,57]. The expression levels of lncRNA G8110 and NFE2L1 were decreased in the WG group, and lncRNA G8110 showed beneficial effects by promoting lipid metabolism and inhibiting adipose inflammation (Figure 4).…”
Section: Discussionmentioning
confidence: 99%
“…However, the appeal of NFE2L1-related cellular and molecular mechanisms consists in different isoforms and SNPs, which are still under investigation. Recently, NFE2L1-related isoforms and SNPs serve as potential therapeutical targets for neurodegenerative diseases [163] and cancer [164], and are receiving increased attention. The value of NFE2L1 for developing precise cancer treatment is immeasurable.…”
Section: Discussionmentioning
confidence: 99%
“…A growing body of evidence reveals that Nrf1 plays a crucial role in regulating intracellular metabolism [29,67,68], because the loss of its function leads to marked metabolic signal reprogramming [67,[69][70][71]. In this process, Nrf1 exerts its unique indispensable functions for governing the intracellular redox and energy (including lipid, cholesterol, glucose) metabolic homeostasis and also maintaining protein homeostasis and even chromosomal stability [20,22,31].…”
Section: The Loss Of Nrf1 Exacerbates Development Of Sasp By Reprogra...mentioning
confidence: 99%
“…The accumulating evidence has suggested that impaired Nrf1 function is much more likely to trigger the occurrence and progression of ageing-related pathologies (e.g., cardiovascular diseases, inflammatory diseases, neurodegenerative diseases), which are evidenced to be closely associated with compromised adaptive responses (i.e., both responses to oxidative and proteotoxic stresses monitored by Nrf1). Conversely, either pharmacological or phytochemical agents that promote Nrf1 activation demonstrated a considerable promise to act as potential targets for the prevention or treatment of age-related disorders [20,29]. Thereby, it is inferable that, as a key regulator of the antioxidant system, Nrf1 has shown its significant potential in protecting cells and organisms from cellular senescence and ageing.…”
Section: Introductionmentioning
confidence: 99%