Unravelling the mosaic: Epigenetic diversity in glioblastoma
Sara Lucchini,
Myrianni Constantinou,
Silvia Marino
Abstract:Glioblastoma is the most common primary malignant brain tumour. Despite decades of intensive research in the disease, its prognosis remains poor, with an average survival of only 14 months after diagnosis. The remarkable level of intra‐ and interpatient heterogeneity is certainly contributing to the lack of progress in tackling this tumour. Epigenetic dysregulation plays an important role in glioblastoma biology and significantly contributes to intratumour heterogeneity. However, it is becoming increasingly cl… Show more
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