2018
DOI: 10.1016/j.cub.2018.02.045
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Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides

Abstract: SummaryThe impact of neonicotinoid insecticides on the health of bee pollinators is a topic of intensive research and considerable current debate [1]. As insecticides, certain neonicotinoids, i.e., N-nitroguanidine compounds such as imidacloprid and thiamethoxam, are as intrinsically toxic to bees as to the insect pests they target. However, this is not the case for all neonicotinoids, with honeybees orders of magnitude less sensitive to N-cyanoamidine compounds such as thiacloprid [2]. Although previous work … Show more

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Cited by 245 publications
(307 citation statements)
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“…A previous study reported that expression of cytochrome P450 genes, a family of genes typically involved in chemical detoxification, is affected by imidacloprid in honeybees (Chaimanee, Evans, Chen, Jackson, & Pettis, ). In line with this, two cytochrome P450 CYP9Q subfamily genes in bumblebees metabolize the neonicotinoid thiacloprid but not imidacloprid (Manjon et al, ). Intriguingly, we found no effect of neonicotinoid exposure on either of these genes, suggesting that the genes do not code for products that metabolize clothianidin, or that they function on different timescales or tissues than our study focused on.…”
Section: Discussionmentioning
confidence: 86%
“…A previous study reported that expression of cytochrome P450 genes, a family of genes typically involved in chemical detoxification, is affected by imidacloprid in honeybees (Chaimanee, Evans, Chen, Jackson, & Pettis, ). In line with this, two cytochrome P450 CYP9Q subfamily genes in bumblebees metabolize the neonicotinoid thiacloprid but not imidacloprid (Manjon et al, ). Intriguingly, we found no effect of neonicotinoid exposure on either of these genes, suggesting that the genes do not code for products that metabolize clothianidin, or that they function on different timescales or tissues than our study focused on.…”
Section: Discussionmentioning
confidence: 86%
“…Although this suggests that there might be large differences in terms of the sensitivity of distantly related species based on phylogenetics (e.g. mammals versus insects), a more recent investigation suggests that pharmacodynamics plays only a secondary role when looking at more closely related species such as bumblebees and honeybees …”
Section: Introductionmentioning
confidence: 99%
“…P450s are an important part of the detoxification and defense system of insects, but this family of monooxygenases is especially limited in honey bees, which may make them more susceptible to negative effects when exposed to combinations of pesticides . The CYP9Q P450 subfamily, expressed in the brain and the Malpighian tubules, among other tissues, has been shown to detoxify the neonicotinoids thiacloprid and acetamiprid in honey bees …”
Section: Introductionmentioning
confidence: 99%