Unravelling the Metastatic Niche in Breast Cancer Patients with Bone Metastasis through Single-cell RNA Sequencing
Xiangyu Li,
Ziyu Gao,
Meiling Yang
et al.
Abstract:Breast cancer (BRCA) is characterized by a unique metastatic pattern and often presents with bone metastasis (BoM), which poses significant clinical challenges. This study employed single-cell RNA sequencing (scRNA-seq) and TCGA data analysis to compare primary tumor (PT), lymph node metastasis (LN), and BoM data. Our investigation identified a metastatic niche in BoMs marked by an increased abundance of cancer-associated fibroblasts (CAFs) and a reduced immune cell count. A distinct subtype (State 1) of BRCA … Show more
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