Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach

Okunlola, Felix O.; Akawa, Oluwole B.; Subair, Temitayo I.; Omolabi, Kehinde F.; Soliman, Mahmoud E. S.

doi:10.1007/s12013-021-01027-3

Cited by 1 publication

(1 citation statement)

References 67 publications

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“…A study by Cheng et al (129) confirmed that Numb is related to EMT and its knockdown promoted EMT through the Wnt signaling pathway, thereby accelerating the formation of colon tumors; furthermore, IWR-1 attenuated EMT caused by Numb knockdown to inhibit the development and progression of colon tumors (129). Of note, it was recently indicated that the TNKS inhibitor bis-quinazolinone 5/Cpd 5 is superior to IWR-1 based on its inhibitory activity and stability, providing a new basis for the development of TNKS inhibitors (130).…”

Section: Pnu-74654 Gb1874 and Inhibitor Of B-catenin And Tcf (Icat) P...mentioning

confidence: 99%

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)

Chen

Deng

2022

Int J Oncol

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Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate among patients with CRC is high. The Wnt/β-catenin signaling pathway, which is associated with carcinogenesis, is abnormally activated in CRC. Most patients with CRC have adenomatous polyposis coli mutations, while half of the remaining patients have β-catenin gene mutations. Therefore, targeting the Wnt/β-catenin signaling pathway for the treatment of CRC is of clinical value. In recent years, with in-depth research on the Wnt/β-catenin signaling pathway, inhibitors have been developed that are able to suppress or hinder the development and progression of CRC. In the present review, the role of the Wnt/β-catenin signaling pathway in CRC is summarized, the research status on Wnt/β-catenin pathway inhibitors is outlined and potential targets for inhibition of this pathway are presented. Contents 1. Introduction 2. Current status of CRC treatments 3. Overview of the Wnt signaling pathway 4. Role of the Wnt/β-catenin signaling pathway in the development and progression of CRC 5.

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Section: Pnu-74654 Gb1874 and Inhibitor Of B-catenin And Tcf (Icat) P...mentioning

confidence: 99%

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)

Chen

Deng

2022

Int J Oncol

View full text Add to dashboard Cite

show abstract

Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach

Cited by 1 publication

References 67 publications

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)

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