Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics

D’Ambrosio, Viola; Ferraro, Pietro Manuel; Lombardi, Gianmarco; Friso, Simonetta; Gambaro, Giovanni

doi:10.3390/nu14234961

Cited by 10 publications

(20 citation statements)

References 120 publications

(141 reference statements)

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“…Various metabolic imbalances (e.g. hyperparathyroidism, hypercortisolism, hyperglycemia), lack of physical activity, lack of essential vitamins and minerals ( 3 )(such as Vitamin B6 and magnesium), blockage of the urinary tract, infection, foreign objects, and drug use are all potential causes of kidney stone formation ( 4 , 5 ). Though the symptoms of kidney stones may be less visible than those of urolithiasis, they can be more severe and can significantly reduce a patient’s quality of life, with the possibility of developing hematuria, pain, urinary tract infection, and renal dysfunction ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Could METS-VF provide a clue as to the formation of kidney stones?

Guo

Chen

et al. 2023

Front. Endocrinol.

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ObjectiveThe lifetime occurrence rate of kidney stones is 14%, making it one of the most prevalent urological conditions. Other contributing elements, such as obesity, diabetes, diet, and heredity, are also taken into account. Our research sought to explore the potential link between high visceral fat scores (METS-VF) and the occurrence of kidney stones, as a means of understanding how to prevent them.MethodsThis research utilized data from the National Health and Nutrition Examination Survey (NHANES), mirroring the demographics of the United States. We carried out an in-depth analysis of the connection between METS-VF and kidney stones, based on data from 29,246 participants in the National Health and Nutrition Examination Survey spanning 2007 to 2018, involving logistic regression, segmentation, and dose-response curve analysis.ResultsOur study of 29,246 potential participants found that METS-VF was positively associated with the prevalence and progression of kidney stones. After subgroup analysis by gender, race, blood pressure, and blood glucose, our results showed that the ORs for METS-VF and kidney stones were (1.49, 1.44) in males and females, respectively; while in Mexicans, whites, blacks, and In other populations, the OR values were (1.33, 1.43, 1.54, 1.86); in hypertensive and normal populations, the OR values were (1.23, 1.48); in diabetic patients and normoglycemic patients were (1.36,1.43). This proves that it works for all groups of people.SummaryOur studies demonstrate a strong connection between METS-FV and the emergence of kidney stones. It would be beneficial to investigate METS-VF as a marker for kidney stone development and progression in light of these findings.

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Section: Introductionmentioning

confidence: 99%

Could METS-VF provide a clue as to the formation of kidney stones?

Guo

Chen

et al. 2023

Front. Endocrinol.

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“…In other words, even in a seemingly normal body, the initial lesion (etiology) is already present. Ironically, episodes of kidney stone formation are said to be a "red flag," a warning sign of arteriosclerosis that has been quietly progressing for many years [55]. Interestingly, in the detection of this very early lesion, there are older studies that have historically been accumulated in the RSD area than in the CVC area.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Unique Spontaneous Calcifying Cell Line (CJ): a Novel Tool for the Study of Ectopic Calcification

Ida,

Yamane

2024

Preprint

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PurposeDue to the lack of an appropriate in vitro evaluation system, there is no effective prevention or treatment for ectopic calcification diseases (ECD). We obtained canine renal adenocarcinoma cells (CJ cells) that spontaneously form large amounts of calcified precipitates (CaP-ppt) and examined whether they could serve as a model for the early stages of ectopic calcification (EC).MethodsDispersed cells obtained by collagenase-DNase digestion were cultured in 10% FBS, antibiotic-containing DMEM-high glucose medium (standard medium). CaP-ppt was stained with Alizarin Red (AR) and colorimetrically quantified after acid extraction. Cell volume was determined by Crystal violet (CV) staining followed by extraction and colorimetric quantification. Calcium (Ca) and phosphate (PO4) were determined with a commercial kit to obtain the Ca/P ratio. Screening of anti-CaP-ppt compounds was performed in the same 96-well plate in the order of cell culture ⇒ CaP-ppt quantification ⇒ cell quantification and evaluated by IC50value.ResultsCJ cells produced large amounts of CaP-ppt on standard medium alone without external phosphate addition; CaP-ppt formation was not accompanied by cell death, but on the contrary, CaP-ppt increased at physiological pH values around pH 7.4 due to active cell metabolism. The Ca2+and PO43-partitioning kinetics to CaP-ppt were found, and the Ca/P ratio of CaP-ppt was stable at 1.35. The anti-Cap-ppt effects of bisphosphonates and all-trans retinoic acid (ATRA) were also confirmed in this CJ cell CaP-ppt system.DiscussionThere was doubt about the vascular calcifying cell model with the addition of high concentrations of phosphoric acid, but there were no suitable alternative cells. Spontaneously calcifying CJ cells provide a fundamental solution to this problem. Anti-CaP-ppt screening also eliminates the need for medium exchange, thus saving labor and cost. The Ca/P ratio of CaP-ppt in CJ cells is 1.35, the same as that of amorphous Ca phosphate (ACP), corresponding to the early (reversible) stage of EC. Therefore, it has favorable conditions as an evaluation system for drug discovery.ConclusionCJ cells, which calcify at physiological phosphate concentrations (0.9 mM) in standard media, are useful and novel research material for basic and preventive studies of ECD and for drug development studies.

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“…Kidney stones can be broadly categorized into calcareous (calcium-containing) and non-calcareous stones [ 7 ]. Calcium-containing stones are radio-opaque and account for almost 75% of cases.…”

Section: Pathophysiology and Main Molecular Mechanisms Of Nephrolithi...mentioning

confidence: 99%

Pathophysiology and Main Molecular Mechanisms of Urinary Stone Formation and Recurrence

Tamborino,

Cicchetti,

Mascitti

et al. 2024

IJMS

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Kidney stone disease (KSD) is one of the most common urological diseases. The incidence of kidney stones has increased dramatically in the last few decades. Kidney stones are mineral deposits in the calyces or the pelvis, free or attached to the renal papillae. They contain crystals and organic components, and they are made when urine is supersaturated with minerals. Calcium-containing stones are the most common, with calcium oxalate as the main component of most stones. However, many of these form on a calcium phosphate matrix called Randall’s plaque, which is found on the surface of the kidney papilla. The etiology is multifactorial, and the recurrence rate is as high as 50% within 5 years after the first stone onset. There is a great need for recurrence prevention that requires a better understanding of the mechanisms involved in stone formation to facilitate the development of more effective drugs. This review aims to understand the pathophysiology and the main molecular mechanisms known to date to prevent recurrences, which requires behavioral and nutritional interventions, as well as pharmacological treatments that are specific to the type of stone.

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Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics

Cited by 10 publications

References 120 publications

Could METS-VF provide a clue as to the formation of kidney stones?

Could METS-VF provide a clue as to the formation of kidney stones?

Characterization of a Unique Spontaneous Calcifying Cell Line (CJ): a Novel Tool for the Study of Ectopic Calcification

Pathophysiology and Main Molecular Mechanisms of Urinary Stone Formation and Recurrence

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