Unravelling the Chemical Influence of Water on the PMMA/Aluminum Oxide Hybrid Interface In Situ

Pletincx, Sven; Marcoen, Kristof; Trotochaud, Lena; Fockaert, Laura-Lynn; Mol, J.M.C.; Head, Ashley R.; Karslıoğlu, Osman; Bluhm, Hendrik; Terryn, Herman; Hauffman, Tom

doi:10.1038/s41598-017-13549-z

Cited by 86 publications

(70 citation statements)

References 52 publications

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“…This behavior has also been observed with other polymers including a study with poly(methyl methacrylate) (PMMA) polymer, Tannebaum et al 45 found that water helps to mediate bonding. Similar observations were recently reported by Pletincx et al 46 using in-situ measurements, showing that water can stabilize the formation of carboxylate bonds on native aluminum oxides.…”

Section: Phenol-base Adhesive (Redux 775)supporting

confidence: 90%

Adhesive Bonding and Corrosion Performance Investigated as a Function of Aluminum Oxide Chemistry and Adhesives

Abrahami

Hauffman

Kok³

et al. 2017

CORROSION

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Section: Phenol-base Adhesive (Redux 775)supporting

confidence: 90%

Adhesive Bonding and Corrosion Performance Investigated as a Function of Aluminum Oxide Chemistry and Adhesives

Abrahami

Hauffman

Kok³

et al. 2017

CORROSION

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“…The typical deconvolution of PMMA C1s spectra is illustrated in Figure 2a-"plain sample" which consists of a hydrocarbon peak CC/CH at 284.57 (±0.1) eV, a beta carbon peak CCO at 285.42 (±0.16) eV, CO bond in methoxy groups at 286.47 (±0.14) eV, and a carboxyl carbon OCO peak at 288.58 (±0.2) eV. [65,66] The peak area (%) of C1s components are shown in Table 1. As seen, oxygen plasma treatment raised the carboxyl carbon peak area from 12.71% to 18.91%, which could be correlated with oxidation of PMMA and formation of carboxyl groups through plasma induced oxygen radicals.…”

Section: Resultsmentioning

confidence: 99%

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Shakeri

Jarad

Terryberry³

et al. 2020

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Recent studies have shown a correlation between elevated interleukin 6 (IL-6) concentrations and the risk of respiratory failure in COVID-19 patients. Therefore, detection of IL-6 at low concentrations permits early diagnosis of worstcase outcome in viral respiratory infections. Here, a versatile biointerface is presented that eliminates nonspecific adhesion and thus enables immunofluorescence detection of IL-6 in whole human plasma or whole human blood during coagulation, down to a limit of detection of 0.5 pg mL −1. The sensitivity of the developed lubricant-infused biosensor for immunofluorescence assays in detecting low molecular weight proteins such as IL-6 is facilitated by i) producing a bioink in which the capture antibody is functionalized by an epoxy-based silane for covalent linkage to the fluorosilanized surface and ii) suppressing nonspecific adhesion by patterning the developed bioink into a lubricant-infused coating. The developed biosensor addresses one of the major challenges for biosensing in complex fluids, namely nonspecific adhesion, therefore paving the way for highly sensitive biosensing in complex fluids. where significantly elevated levels indicate aggressive tumor growth or viral load and poor prognosis in patients. [2,10] Additionally, IL-6 is an important anti-inflammatory cytokine that induces acute responses in chronic inflammatory pathologies. As such, there has been an increasing interest in the use of IL-6 as a biomarker for the diagnosis of early stages of viral infections, cancer, and chronic inflammation. [9-11] A practical IL-6 biosensor should provide a low limit of detection (LOD) (≤5 pg mL −1) and acceptable linear dynamic range (1-100 pg mL −1) in complex fluids, in addition to accuracy, facile operation, and amenable to mass production. [11,12] There are a large number of different IL-6 detection techniques that have been reported in the literature including electrochemical sensors, [13-22] surface plasmon resonance (SPR), [23-25] chemiluminescence immunoassay (CLIA), [26-29] and immunofluorescence assays (IFA), [30-33] Utilizing 0-and 1-D materials such as carbon nanotubes (CNTs), [14,16] nanoparticles and nanowires, [13,19] as well as porous nanoparticles, [15] optical fibers, [32] and microfluidic platforms, [28] have enabled higher sensitivity in IL-6 detection and to date, electrochemical methods have proven to be the most promising candidate for detection of IL-6 at very low concentrations (0.33 pg mL −1 in buffer) with a wide linear dynamic range. [22] While reported IL-6 biosensors have demonstrated satisfactory LODs in buffer or processed serum, their performance in human whole plasma declines significantly, leading to higher LOD's and/or false positive results. In electrochemical sensors, for example, the nonspecific attachment of biological entities in plasma or blood can interfere with the resistivity at the electrodes thereby deteriorating their sensitivity for detection of IL-6 at clinically relevant concentrations. [34] So far, the lowest theoretical LOD fo...

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“…In the nanocomposite systems, a lower number of studies using NAP-XPS can be found in the literature regarding the interaction of relevant molecules with inorganic fillers on or near the surface of the nanocomposite, e.g., the chemical state of Pt in Pt/C electrodes under humid condition [148]. Probing the interaction at organic/inorganic interfaces was recently attempted: Pletincx et al investigated the mechanism of the interactions among three components of water vapor, poly(methyl methacrylate) (PMMA) chain, and aluminum oxide surface [149]. Careful in situ examination of C(1s) and O(1s) NAP-XPS spectra suggested that water played an important role to induce hydrolysis of methyl ester group in PMMA to carboxylic acid, which is relevant for the strong adsorption of the polymer chain on the oxide surface [150].…”

Section: New Opportunity With Emerging X-ray Based Techniques Enablinmentioning

confidence: 99%

X-ray-Based Spectroscopic Techniques for Characterization of Polymer Nanocomposite Materials at a Molecular Level

et al. 2020

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This review provides detailed fundamental principles of X-ray-based characterization methods, i.e., X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, and near-edge X-ray absorption fine structure, and the development of different techniques based on the principles to gain deeper understandings of chemical structures in polymeric materials. Qualitative and quantitative analyses enable obtaining chemical compositions including the relative and absolute concentrations of specific elements and chemical bonds near the surface of or deep inside the material of interest. More importantly, these techniques help us to access the interface of a polymer and a solid material at a molecular level in a polymer nanocomposite. The collective interpretation of all this information leads us to a better understanding of why specific material properties can be modulated in composite geometry. Finally, we will highlight the impacts of the use of these spectroscopic methods in recent advances in polymer nanocomposite materials for various nano- and bio-applications.

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Unravelling the Chemical Influence of Water on the PMMA/Aluminum Oxide Hybrid Interface In Situ

Cited by 86 publications

References 52 publications

Adhesive Bonding and Corrosion Performance Investigated as a Function of Aluminum Oxide Chemistry and Adhesives

Adhesive Bonding and Corrosion Performance Investigated as a Function of Aluminum Oxide Chemistry and Adhesives

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

X-ray-Based Spectroscopic Techniques for Characterization of Polymer Nanocomposite Materials at a Molecular Level

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