Unravelling key enzymatic steps in C-ring cleavage during angucyclines biosynthesis
Somayah Elsayed,
Helga van der Heul,
Xiansha Xiao
et al.
Abstract:Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively studied, little is known of the enzymes leading to C-ring cleavage. Here, we unravel the function of the oxygenases involved in the biosynthesis of lugdunomycin, a highly rearranged C-ring cleaved angucycline derivative. Targeted deletion of the oxygenase genes, in combinati… Show more
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