Unraveling the Ties between Celiac Disease and Intestinal Microbiota

Sanz, Yolanda; G, De Pama; Laparra, Moisés

doi:10.3109/08830185.2011.599084

Cited by 123 publications

(100 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, deviations in faecal and duodenal microbiota associated with CD have been reported (149,(151)(152)(153) , although recent studies utilising high-throughput methods have reported comparable microbiota compositions in patients and healthy controls (154)(155)(156)(157) . A recent study utilising a highthroughput microarray method in analysing duodenal biopsies of paediatric CD patients in Finland found that while the overall microbiota composition was comparable between CD and healthy subjects, a profile of eight bacterial groups was observed to distinguish patients from healthy controls (157) .…”

Section: Coeliac Diseasementioning

confidence: 99%

“…in faeces and duodenal biopsies of CD patients (152,153,163) , although a complete lack of the members of phylum Bacteroidetes was observed in CD predisposed infants in a prospective study (149) . Furthermore, another study reported a reduction in IgA-coated bacteria, especially IgA-coated Bacteroides in faeces of untreated and treated CD patients when compared to healthy controls (151) . The authors stated that host defences against this bacterial group might be reduced in coeliac disease, thus allowing its increased colonisation.…”

Section: Coeliac Diseasementioning

confidence: 99%

“…A specific role for the intestinal microbiota in CD development has been suggested (149,151,152) . Indeed, deviations in faecal and duodenal microbiota associated with CD have been reported (149,(151)(152)(153) , although recent studies utilising high-throughput methods have reported comparable microbiota compositions in patients and healthy controls (154)(155)(156)(157) .…”

Section: Coeliac Diseasementioning

confidence: 99%

See 2 more Smart Citations

Intestinal microbiota during early life – impact on health and disease

et al. 2014

View full text Add to dashboard Cite

In the first years after birth, the intestinal microbiota develops rapidly both in diversity and complexity while being relatively stable in healthy adults. Different life-style-related factors as well as medical practices have an influence on the early-life intestinal colonisation. We address the impact of some of these factors on the consecutive microbiota development and later health. An overview is presented of the microbial colonisation steps and the role of the host in that process. Moreover, new early biomarkers are discussed with examples that include the association of microbiota and atopic diseases, the correlation of colic and early development and the impact of the use of antibiotics in early life. Our understanding of the development and function of the intestinal microbiota is constantly improving but the long-term influence of early-life microbiota on later life health deserves careful clinical studies.Microbiota development: Human milk oligosaccharides: Weaning: Biomarker bacteria:Allergy and atopic diseases: Colic: Antibiotics

show abstract

Section: Coeliac Diseasementioning

confidence: 99%

Section: Coeliac Diseasementioning

confidence: 99%

Section: Coeliac Diseasementioning

confidence: 99%

See 1 more Smart Citation

Intestinal microbiota during early life – impact on health and disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…41 Other possibilities for how gluten may be related to depression include abnormalities of serotonin production, 42 or gluten exorphins interfering with the CNS, 43 or changes in the gut microbiota. 44 It should be emphasized that the tool used to assess depression in this study was one self-administered questionnaire, and the clinical significance of these findings requires further research using additional measures of depression and of longer duration. Currently, there is no evidence for efficacy of gluten exclusion in mental disorders, 8,45 therefore care must be given when discussing these early results and awareness given to understanding that a major effect of gluten in NCGS patients may be in the perception of their general well-being.…”

Section: Potential Mechanismsmentioning

confidence: 99%

Non‐coeliac gluten sensitivity: piecing the puzzle together

Biesiekierski

Iven

2015

UEG Journal

View full text Add to dashboard Cite

The avoidance of wheat-and gluten-containing products is a worldwide phenomenon. While coeliac disease is wellestablished, much remains unknown about whether gluten can be a trigger of gastrointestinal and/or extra-intestinal symptoms in patients without coeliac disease. In this article, we discuss the latest scientific evidence and our current understanding for the possible mechanisms of this largely ambiguous group, termed 'non-coeliac gluten sensitive' (NCGS). We can conclude that NCGS should be regarded as an independent disease outside of coeliac disease and wheat allergy, and that the number of patients affected is likely to be limited. Many questions remain unanswered and it needs to be verified whether the elimination of dietary gluten alone is sufficient for the control of symptoms, and to understand the overlap with other components of wheat.

show abstract

“…Others have noted a relationship between gut bacteria and CD development (Forsberg et al 2004;Ou et al 2009;Sanz et al 2011;Sjöberg et al 2013). Most recently, Sjöberg and colleagues (2013) Although the analogy is not entirely apt, we can contrast the pattern of CD with the global pattern of lactose intolerance (lactase persistence), in which the populations with the longest history of dairying and milk consumption are those with the greatest adaptation to lactose digestion.…”

Section: Presentation Pathophysiology and Genetics Of CDmentioning

confidence: 99%

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Sams

Hawks

2014

Human Biology

View full text Add to dashboard Cite

Abstract. Celiac disease (CD) is a multifactorial chronic inflammatory conditionthat results in injury of the mucosal lining of the small intestine upon ingestion of wheat gluten and related proteins from barley and rye. Although the exact mechanisms leading to CD are not fully understood, the genetic basis of CD has been relatively well characterized. In this review we briefly review the history of discovery, clinical presentation, pathophysiology, and current understanding of the genetics underlying CD risk. Then, we discuss what is known about the current distribution and evolutionary history of genes underlying CD risk in light of other evolutionary models of disease. Specifically, we conclude that the set of loci underlying CD risk did not cohesively evolve as a response to a single past selection event such as the development of agriculture. Rather, deterministic and stochastic evolutionary processes have both contributed to the present distribution of variation in CD risk loci. Selection has shaped some components of this network, but this selection appears to have occurred at different points in the past.Other parts of the CD risk network have likely arisen due to stochastic processes such as genetic drift. Celiac disease (CD) is a multifactorial chronic inflammatory condition that resultsin injury of the mucosal lining of the small intestine. The earliest descriptions of a condition with symptoms like CD date back to the first and second century writings of the Greek physician Arataeus (Simoons 1981;Losowsky 2008). The first modern description of CD is attributed to English physician Samuel Jones Gee, who was familiar with the writings of Arataeus. In 1888 (Dowd and Walker-Smith 1974;Simoons 1981;Losowsky 2008) Gee described the 'coeliac affection' as a condition of chronic indigestion associated with diarrhea, wasting, and weakness and common in people of all ages. Gee's report was the first to hypothesize dietary factors as a primary cause of the condition (Dowd and Walker-Smith 1974), and during the early twentieth century some workers noted the value of a starch free diet for prevention of CD (Haas 1924). Dicke and colleagues (1950, 1953) observed the detrimental effect of wheat flour (but not wheat starch) on CD patients experimentally confirming a role for diet as a driver of CD. Shortly thereafter, Anderson and colleagues (Anderson et al. 1952;Alvey et al. 1957) confirmed the effect of wheat on CD and identified wheat gluten as the primary culprit.CD appears to be an evolutionary paradox. Only since the 1950s have clinicians recognized that a gluten-free diet is an effective treatment (Barker and Liu 2008). Before that time, diagnosed and undiagnosed CD reduced the health and fitness of sufferers, with juvenile cases leading to malnutrition or death, and adult cases causing wasting, lack of adequate nutrition, greater susceptibility to infection, and direct reductions in fertility (Corrao et al. 2001;Soni and Badawy 2010). Despite these apparent costs, CD is common today (>1%) in several popul...

show abstract

Unraveling the Ties between Celiac Disease and Intestinal Microbiota

Cited by 123 publications

References 56 publications

Intestinal microbiota during early life – impact on health and disease

Intestinal microbiota during early life – impact on health and disease

Non‐coeliac gluten sensitivity: piecing the puzzle together

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Contact Info

Product

Resources

About