Unraveling the therapeutic potential of carbamoyl phosphate synthetase 1 (CPS1) in human diseases

Zhang, Lan; Zou, Yuling; Lü, Yingying; Li, Zhijia; Gao, Feng

doi:10.1016/j.bioorg.2022.106253

Cited by 4 publications

(1 citation statement)

References 93 publications

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“…CPS1 was thought to be involved in metabolic reprogramming in hepatocellular carcinoma, thus affecting the occurrence of tumors (30). The development of inhibitors for CPS1 also shows potential therapeutic potential (31). The high expression of HMGA2 in lung cancer indicates a worse prognosis, which is consistent with our findings.…”

Section: Discussionsupporting

confidence: 91%

A novel zinc metabolism-related gene signature to predict prognosis and immunotherapy response in lung adenocarcinoma

Chang

et al. 2023

Front. Immunol.

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BackgroundZinc is a key mineral element in regulating cell growth, development, and immune system. We constructed the zinc metabolism-related gene signature to predict prognosis and immunotherapy response for lung adenocarcinoma (LUAD).MethodsZinc metabolism-associated gene sets were obtained from Molecular Signature Database. Then, the zinc metabolism-related gene signature (ZMRGS) was constructed and validated. After combining with clinical characteristics, the nomogram for practical application was constructed. The differences in biological pathways, immune molecules, and tumor microenvironment (TME) between the different groups were analyzed. Tumor Immune Dysfunction and Exclusion algorithm (TIDE) and two immunotherapy datasets were used to evaluate the immunotherapy response.ResultsThe signature was constructed according to six key zinc metabolism-related genes, which can well predict the prognosis of LUAD patients. The nomogram also showed excellent prediction performance. Functional analysis showed that the low-risk group was in the status of immune activation. More importantly, the lower risk score of LUAD patients showed a higher response rate to immunotherapy.ConclusionThe state of zinc metabolism is closely connected to prognosis, tumor microenvironment, and response to immunotherapy. The zinc metabolism-related signature can well evaluate the prognosis and immunotherapy response for LUAD patients.

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Section: Discussionsupporting

confidence: 91%